环状PDZD8通过海绵化miR-197-5p调控CHD9促进胃癌进展。
CircPDZD8 promotes gastric cancer progression by regulating CHD9 via sponging miR-197-5p.
作者信息
Xia Tianfang, Pan Zhenguo, Zhang Jie
机构信息
Department of General Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, Huaiyin, Jiangsu Province, China.
Department of Gastroenterology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaiyin 223300, Huaian, Jiangsu Province, China.
出版信息
Aging (Albany NY). 2020 Oct 13;12(19):19352-19364. doi: 10.18632/aging.103805.
CircRNAs have been shown to be associated with gastric cancer tumorigenesis. But little was known about the role of circPDZD8 in gastric cancer. CircPDZD8 was up-regulated in gastric cancer tissues and cells, Kaplan-Meier survival analysis indicated that gastric patients had a poor overall survival when circPDZD8 levels were high. CircPDZD8 knockdown could hinder proliferation and migration of gastric cancer cells. MiR-197-5p, which was down-regulated in gastric cancer, was shown to be a target of circPDZD8 and was inversely correlated with circPDZD8 expression. CHD9, as a target gene of miR-197-5p, was negatively regulated by miR-197-5p and positively correlated with circPDZD8 expression. Importantly, circPDZD8 could up-regulate CHD9 expression by sponging miR-197-5p, and modulate cell progression by regulation of the miR-197-5p/CHD9 axis in gastric cancer. CircPDZD8 knockdown repressed the progression of gastric cancer cells by sponging miR-197-5p and down-regulating CHD9.
环状RNA已被证明与胃癌的发生有关。但关于circPDZD8在胃癌中的作用知之甚少。circPDZD8在胃癌组织和细胞中上调，Kaplan-Meier生存分析表明，当circPDZD8水平较高时，胃癌患者的总生存期较差。circPDZD8敲低可阻碍胃癌细胞的增殖和迁移。在胃癌中表达下调的miR-197-5p被证明是circPDZD8的靶标，且与circPDZD8表达呈负相关。CHD9作为miR-197-5p的靶基因，受到miR-197-5p的负调控，并与circPDZD8表达呈正相关。重要的是，circPDZD8可通过吸附miR-197-5p上调CHD9表达，并通过调节胃癌中的miR-197-5p/CHD9轴来调节细胞进程。circPDZD8敲低通过吸附miR-197-5p和下调CHD9抑制胃癌细胞的进程。
Zotero 插件