School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
Carbohydr Polym. 2020 Dec 15;250:116996. doi: 10.1016/j.carbpol.2020.116996. Epub 2020 Aug 29.
Solid self-nanoemulsifying drug delivery system (S-SENDDS) containing Curcumin (CRM) were prepared using combination of Ganoderma lucidum extract powder (GLEP) and probiotics (PB) as carriers. Liquid SNEDDS containing CRM were prepared by mixing Capmul MCM, Labrafil M1944CS, Tween 80 and Transcutol P. These were further spray dried and finally converted into spheroids. The droplet size of reconstituted S-SNEDDS powder and spheroids was found in the range of 35 to 37 nm, zeta potential in the range of - 21.48 to -23.22 mV and drug loading in the range of 95-96%. The release of drug from formulations was found to be more than 90%. Similarly, significant improvement (p < 0.05) in permeability of CRM was observed through SNEDDS using Caco2 cell lines. The non-significant difference (p> 0.05) in drug loading, droplet size, dissolution rate and angle of repose between L-SNEDDS and S-SNEDDS indicated the potential of GLEP-PB to produce stable SNEDDS.
载有姜黄素（CRM）的固体自微乳给药系统（S-SENDDS）是通过将灵芝提取物粉末（GLEP）和益生菌（PB）组合作为载体制备的。含有 CRM 的液体 SNEDDS 通过混合 Capmul MCM、Labrafil M1944CS、Tween 80 和 Transcutol P 制备。然后将其进一步喷雾干燥，并最终转化为球体。重建的 S-SNEDDS 粉末和球体的粒径在 35 至 37nm 之间，zeta 电位在-21.48 至-23.22mV 之间，药物载量在 95-96%之间。制剂中药物的释放率超过 90%。同样，通过 Caco2 细胞系的 SNEDDS 观察到 CRM 通透性有显著提高（p < 0.05）。L-SNEDDS 和 S-SNEDDS 之间药物载量、粒径、溶出率和休止角无显著差异（p> 0.05），表明 GLEP-PB 具有产生稳定 SNEDDS 的潜力。
