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洋葱提取物在管理继发腹部肥大性瘢痕形成中的功效。

The efficacy of onion extract in the management of subsequent abdominal hypertrophic scar formation.

机构信息

Süleymaniye Maternity Research and Training Hospital, Obstetrics and Gynecology Clinic, Zeytinburnu, Istanbul, Turkey.

出版信息

J Wound Care. 2020 Oct 2;29(10):612-616. doi: 10.12968/jowc.2020.29.10.612.

Abstract

OBJECTIVE

Development of postoperative scars is often a problem. This study aimed to evaluate the efficacy of gel containing extract, allantoin and heparin (Contractubex, Merz Pharmaceuticals GmbH, Frankfurt, Germany) in reducing scarring after a caesarean section by comparing it with a control group, and also intra-individually, using the Vancouver Scar Scale (VSS).

METHOD

A total of 120 patients who underwent a second elective caesarean delivery and who presented with hypertrophic scar development after their first caesarean section were included in the study. A scar revision was performed for all patients during the second caesarean operation. Patients in the study group (n=60) were advised to apply the topical scar gel postoperatively for a period of 6 months. The control group (n=60) received no treatment.

RESULTS

Significant reductions were observed in the vascularity, pigmentation and height subgroups of the VSS for those in the group who continued the treatment to 24 weeks. An intra-individual analysis showed that the gel effectively reduced scarring after the second caesarean section.

CONCLUSION

The prophylactic use of the gel to reduce scar development offers better results for vascularity, pigmentation and height subscales of the VSS after surgical removal of the primary caesarean scar during the second caesarean section. The results were better both intra-individually, and also in comparison with the control group and support the use of a gel containing extract, allantoin and heparin to reduce scarring after a caesarean section.

摘要

目的

术后瘢痕的形成通常是一个问题。本研究旨在通过温哥华瘢痕量表(VSS)评估比较含 提取物、尿囊素和肝素的凝胶(德国美兹制药有限公司的 Contractubex)与对照组相比在减少剖宫产术后瘢痕形成方面的疗效,并进行个体内比较。

方法

共纳入 120 例因第二次选择性剖宫产术且首次剖宫产术后出现增生性瘢痕的患者。所有患者在第二次剖宫产术中均进行了瘢痕修整。研究组(n=60)患者术后建议使用外用瘢痕凝胶治疗 6 个月。对照组(n=60)未接受治疗。

结果

治疗至 24 周时,VSS 的血管、色素和高度亚组观察到显著降低。个体内分析显示,该凝胶在第二次剖宫产术后能有效减轻瘢痕形成。

结论

在第二次剖宫产术时切除原发性剖宫产瘢痕后,预防性使用该凝胶可减少血管、色素和高度亚组的 VSS 评分,结果无论是个体内比较还是与对照组比较均更好,支持使用含 提取物、尿囊素和肝素的凝胶来减少剖宫产术后的瘢痕形成。

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