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Gemtuzumab ozogamicin is efficacious in attaining complete remission in relapsed/refractory acute leukemia prior to hematopoietic cell transplant: A case series.

作者信息

Fatobene Giancarlo, Souza Gabriela Rodriguez de, Rodrigues Celso Arrais, Novis Yana Augusta Sarkis, Rocha Vanderson

机构信息

Sírio-Libanês Hospital, São Paulo, SP, Brazil; Instituto do Câncer do Estado de São Paulo da Universidade de São Paulo (ICESP USP), São Paulo, SP, Brazil; Laboratório Investigação Médica em Patogênese e Terapia dirigida em Onco-Imuno-Hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (LIM/31 HCFMUSP), São Paulo, SP, Brazil.

Sírio-Libanês Hospital, São Paulo, SP, Brazil.

出版信息

Hematol Transfus Cell Ther. 2021 Oct-Dec;43(4):532-536. doi: 10.1016/j.htct.2020.07.008. Epub 2020 Sep 13.

DOI:10.1016/j.htct.2020.07.008
PMID:33055008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8573029/
Abstract
摘要

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Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia.吉妥单抗奥佐米星治疗晚期CD33+急性髓性白血病儿科患者的安全性和有效性。
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本文引用的文献

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The EMA Review of Mylotarg (Gemtuzumab Ozogamicin) for the Treatment of Acute Myeloid Leukemia.EMA 审查米妥莫单抗（吉妥珠单抗奥佐米星）治疗急性髓细胞白血病。
Oncologist. 2019 May;24(5):e171-e179. doi: 10.1634/theoncologist.2019-0025. Epub 2019 Mar 21.
2
Gemtuzumab ozogamicin in acute myeloid leukemia: act 2, with perhaps more to come.吉妥单抗奥唑米星治疗急性髓系白血病：第二阶段，或许后续还有更多进展。
Haematologica. 2019 Jan;104(1):7-9. doi: 10.3324/haematol.2018.205948.
3
Salvage regimens using conventional chemotherapy agents for relapsed/refractory adult AML patients: a systematic literature review.挽救治疗方案：采用常规化疗药物治疗复发/难治性成人 AML 患者：系统文献复习。
Ann Hematol. 2018 Jul;97(7):1115-1153. doi: 10.1007/s00277-018-3304-y. Epub 2018 Apr 21.
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Salvage therapy for relapsed or refractory acute myeloid leukemia.挽救性治疗复发或难治性急性髓系白血病。
Ther Adv Hematol. 2011 Apr;2(2):73-82. doi: 10.1177/2040620711402533.
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Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study.吉妥珠单抗奥佐米星治疗初治成人急性髓系白血病的疗效（ALFA-0701）：一项随机、开放标签、3 期研究。
Lancet. 2012 Apr 21;379(9825):1508-16. doi: 10.1016/S0140-6736(12)60485-1. Epub 2012 Apr 5.
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Large interindividual differences in cellular sensitivity to calicheamicin may influence gemtuzumab ozogamicin response in acute myeloid leukemia.
Leukemia. 2008 Dec;22(12):2284-5. doi: 10.1038/leu.2008.147. Epub 2008 Jun 19.
7
High efficacy and safety profile of fractionated doses of Mylotarg as induction therapy in patients with relapsed acute myeloblastic leukemia: a prospective study of the alfa group.分次剂量的米托蒽醌作为复发急性髓细胞白血病患者诱导治疗的高效性和安全性：阿尔法组的前瞻性研究
Leukemia. 2007 Jan;21(1):66-71. doi: 10.1038/sj.leu.2404434. Epub 2006 Oct 19.
8
Gemtuzumab ozogamicin in pediatric CD33-positive acute lymphoblastic leukemia: first clinical experiences and relation with cellular sensitivity to single agent calicheamicin.吉妥珠单抗奥唑米星治疗儿童CD33阳性急性淋巴细胞白血病：首次临床经验及与对单药卡奇霉素细胞敏感性的关系
Leukemia. 2003 Feb;17(2):468-70. doi: 10.1038/sj.leu.2402749.
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Cancer Chemother Pharmacol. 2002 Dec;50(6):497-500. doi: 10.1007/s00280-002-0539-y. Epub 2002 Oct 22.
10
Expression of myeloid markers lacks prognostic impact in children treated for acute lymphoblastic leukemia: Italian experience in AIEOP-ALL 88-91 studies.髓系标志物的表达对接受急性淋巴细胞白血病治疗的儿童无预后影响：意大利在AIEOP-ALL 88-91研究中的经验。
Blood. 1998 Aug 1;92(3):795-801.