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化脓性汗腺炎的病因是什么?——15 年后的研究进展

What causes hidradenitis suppurativa ?-15 years after.

机构信息

European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

出版信息

Exp Dermatol. 2020 Dec;29(12):1154-1170. doi: 10.1111/exd.14214.

DOI:10.1111/exd.14214
PMID:33058306
Abstract

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy." (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as "the only inflammatory skin disease than can be healed". This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future.

摘要

第一篇关于化脓性汗腺炎(HS)发病机制的综述文章的 14 位作者于 2008 年在《实验皮肤病学》上发表,该文章是在 2006 年 3 月 30 日至 4 月 2 日于德国德绍举行的第一届国际化脓性汗腺炎研究研讨会上总结得出的,共有 33 位参与者。他们当时写道:“希望这预示着一个受欢迎的新传统的到来:深入了解 HS 的发病机制,这只能通过扎实的基础 HS 研究的复兴来实现,因为这是开发更有效的 HS 治疗方法的关键。”(Kurzen 等人,《化脓性汗腺炎的病因是什么?》,实验皮肤病学 2008 年;17:455)。15 年后,毫无疑问,人们所期望的扎实的基础 HS 研究的复兴正在迅速推进,HS 在皮肤病学及其他领域的炎症性疾病中已经根深蒂固,被认为是“唯一可以治愈的炎症性皮肤病”。这篇由来自全球 43 位研究人员撰写的纪念文章,刊登在欧洲化脓性汗腺炎基金会(EHSF e.V.)和化脓性汗腺炎基金会(HSF USA)的官方期刊上,总结了过去 15 年来 HS 临床和实验研究的所有方面的证据,并提供了未来几年即将发生的发展情况的信息。

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