Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
Department of Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48105, USA.
Adv Mater. 2020 Nov;32(46):e2002990. doi: 10.1002/adma.202002990. Epub 2020 Oct 15.
Adjuvants play a critical role in the design and development of novel vaccines. Despite extensive research, only a handful of vaccine adjuvants have been approved for human use. Currently used adjuvants are mostly composed of components that are non-native to the human body, such as aluminum salt, bacterial lipids, or foreign genomic material. Here, a new ionic-liquid-based adjuvant is explored, synthesized using two metabolites of the body, choline and lactic acid (ChoLa). ChoLa distributes the antigen efficiently upon injection, maintains antigen integrity, enhances immune infiltration at the injection site, and leads to a potent immune response against the antigen. Thus, it can serve as a promising safe adjuvant platform that can help to protect against pandemics and future infectious threats.
佐剂在新型疫苗的设计和开发中起着关键作用。尽管进行了广泛的研究，但只有少数几种疫苗佐剂被批准用于人体。目前使用的佐剂大多由人体非天然成分组成，如铝盐、细菌脂质或外来基因组材料。在这里，研究人员探索了一种新的基于离子液体的佐剂，该佐剂使用体内的两种代谢物胆碱和乳酸（ChoLa）合成。ChoLa 在注射时能有效地分配抗原，保持抗原完整性，增强注射部位的免疫浸润，并引发针对抗原的强烈免疫反应。因此，它可以作为一种有前途的安全佐剂平台，有助于预防大流行和未来的感染威胁。
