ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India.
College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (CAU), Aizwal, Mizoram, India.
Biofouling. 2020 Sep;36(8):938-950. doi: 10.1080/08927014.2020.1833192. Epub 2020 Oct 15.
Biofilm production, hitherto an uncharacterized feature among circulating strains, was studied along with the antibiotic susceptibility pattern. On the basis of biofilm formation ability, all the strains were categorized into four groups under six different culture conditions: strong biofilm-forming (22%), moderate (19%), weak (51%), and non-adherent (7%). Strains from serogroups A and B formed significant biofilms in at least one culture condition whereas strains from serogroup D were unable to form biofilms. All strains were found to be susceptible to tetracycline. In addition, the correlation between diverse factors (host, capsule type, clinical condition and the gene) as well as antimicrobial susceptibility in biofilm production were analyzed by Joint distribution models, and showed that enrofloxacin and azithromycin resistant strains were positively correlated with strong biofilm production.
生物膜的产生在以往的循环菌株中尚未被描述，因此对其进行了研究，并同时检测了抗生素敏感性模式。根据生物膜形成能力，所有菌株在 6 种不同的培养条件下被分为 4 组：强生物膜形成（22%）、中（19%）、弱（51%）和不附着（7%）。血清组 A 和 B 的菌株在至少一种培养条件下形成了显著的生物膜，而血清组 D 的菌株则不能形成生物膜。所有菌株对四环素均敏感。此外，通过联合分布模型分析了不同因素（宿主、荚膜类型、临床状况和 基因）与生物膜产生中的抗生素敏感性之间的相关性，结果表明恩诺沙星和阿奇霉素耐药菌株与强生物膜产生呈正相关。
