Institut du Cerveau et de la Moelle épinière, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique unités mixtes de recherche 7225, Sorbonne Université, Paris, France.
Institut du Cerveau et de la Moelle épinière, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique unités mixtes de recherche 7225, Sorbonne Université, Paris, France; Neurosurgery Department, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 May;6(5):556-567. doi: 10.1016/j.bpsc.2020.08.002. Epub 2020 Aug 11.
Subthalamic nucleus (STN) deep brain stimulation alleviates obsessive-compulsive disorder (OCD) symptoms, suggesting that this basal ganglia structure may play a key role in integrating limbic and motor information. We explored the modulation of STN neural activity by visual emotional information under different motor demands.
We compared STN local field potentials acquired in 7 patients with OCD and 15 patients with Parkinson's disease off and on levodopa while patients categorized pictures as unpleasant, pleasant, or neutral and pressed a button for 1 of these 3 categories depending on the instruction.
During image presentation, theta power increased for unpleasant compared with neutral images in both patients with OCD and patients with Parkinson's disease. Only in patients with OCD was theta power also increased in pleasant compared with neutral trials. During the button press in patients with OCD, no modification of STN activity was seen on average, but theta power increased when the image triggering the motor response was unpleasant. Conversely, in patients with Parkinson's disease, a beta decrease was observed during the button press unrelated to the valence of the stimulus. Finally, in patients with OCD, a significant positive relationship was observed between the amplitude of the emotionally related theta response and symptom severity (measured using the Yale-Brown Obsessive Compulsive Scale).
We highlighted modulations of STN theta band activity related to emotions that were specific to OCD and correlated with OCD symptom severity. STN theta-induced activity might therefore underlie dysfunction of the limbic STN and its related network leading to OCD pathophysiology.
丘脑底核（STN）深部脑刺激可缓解强迫症（OCD）症状，这表明该基底节结构可能在整合边缘和运动信息方面发挥关键作用。我们探讨了在不同运动需求下视觉情绪信息对 STN 神经活动的调节。
我们比较了 7 例 OCD 患者和 15 例帕金森病患者在停用和服用左旋多巴时的 STN 局部场电位，患者根据指令将图片归类为不愉快、愉快或中性，并按下按钮选择这 3 个类别之一。
在图像呈现期间，与中性图像相比，OCD 患者和帕金森病患者的θ功率在不愉快图像中均增加。只有在 OCD 患者中，θ功率在愉快图像中也比中性试验增加。在 OCD 患者进行按钮按压期间，STN 活动平均没有变化，但当触发运动反应的图像令人不快时，θ 功率增加。相反，在帕金森病患者中，观察到与刺激效价无关的β波下降。最后，在 OCD 患者中，与情绪相关的θ反应幅度与症状严重程度（使用耶鲁-布朗强迫症量表测量）之间存在显著正相关。
我们强调了与 OCD 特异性相关的 STN θ 波段活动的调制，并且与 OCD 症状严重程度相关。因此，STN 诱导的θ活动可能是 OCD 病理生理学中边缘 STN 及其相关网络功能障碍的基础。
