Morishita Y, Hashiguchi M, Ishibe R, Kawashima S, Uehara K, Kamimura R, Chosa N, Taira A
Jpn J Surg. 1987 Mar;17(2):118-22. doi: 10.1007/BF02470651.
To assess the feasibility and function of small donor hearts for large recipients, small donor hearts were orthotopically transplanted into large recipients. Thirty adult mongrel dogs were used to form donor-recipient (D-R) combinations with the D-R heart weight ratio ranging from 0.47 to 1.78. In the D-R heart weight ratio of 0.8 or above (mean 1.11, Group I), the successful transplantation rate was 57 per cent, while it was 81 per cent in cases of less than 0.8 (mean 0.67, Group II) (no statistical difference). In 10 dogs (5 with D/R heart weight ratio greater than or equal to 0.8, 5 with less than 0.8) a recovery rate in cardiac function of the transplanted small heart was studied 2 hours following transplantation. There was no significant difference, hemodynamically in the normal range of left atrial pressure (LAP) between the two groups. The close relationship between cardiac output (CO) and volume load in the range of 10 to 15 mmHg of LAP was transformed to a linear function in the over 0.8 group. It was technically and hemodynamically possible to transplant small dog hearts to larger recipients up to the D-R heart weight ratio of 0.47. The importance of an adequate heart rate for the increase of CO in transplanted smaller donor hearts was emphasized.
为评估小供体心脏用于大受体的可行性及功能，将小供体心脏原位移植到大受体体内。选用30只成年杂种犬，构建供体 - 受体（D - R）组合，D - R心脏重量比在0.47至1.78之间。在D - R心脏重量比为0.8及以上（平均1.11，第一组）时，成功移植率为57%，而在小于0.8（平均0.67，第二组）的情况下，成功移植率为81%（无统计学差异）。对10只犬（5只D/R心脏重量比大于或等于0.8，5只小于0.8）在移植后2小时研究移植的小心脏的心功能恢复率。两组间在左心房压力（LAP）正常范围内的血流动力学无显著差异。在LAP为10至15 mmHg范围内，心输出量（CO）与容量负荷之间的密切关系在心脏重量比大于0.8的组中转变为线性函数。将小狗心脏移植到心脏重量比达0.47的较大受体在技术上和血流动力学上是可行的。强调了适当心率对移植较小供体心脏中CO增加的重要性。
