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晚期冠状动脉支架感染:经皮冠状动脉介入治疗后一种难以诊断的罕见并发症。

Late coronary stent infection: a difficult to diagnose rare complication after percutaneous coronary intervention.

作者信息

Shah Dhiren, Chag Milan, Shah Deepa, Naik Dhaval, Chandan Amit, Sheth Chintan, Bhavsar Niren, Dholakiya Hiren, Bhatt Parloop

机构信息

Department of Cardiac Surgery, CIMS Hospital, Ahmedabad, India.

Care Institute of Medical Sciences, Science City Road, Ahmedabad, India.

出版信息

Indian J Thorac Cardiovasc Surg. 2019 Jan;35(1):74-77. doi: 10.1007/s12055-018-0698-z. Epub 2018 Aug 9.

Abstract

Percutaneous transluminal coronary angioplasty (PTCA) with drug-eluting stent placement is a well-established treatment modality for coronary stenotic lesions. Although infection involving implanted stent is rare, it can occur at any point of time, leading to high morbidity and mortality. We describe a rare case of infected coronary stents complicated with recurrent stent thrombosis, sepsis, and myocardial abscess formation after 2 years of percutaneous cornary intervention (PCI). Using multi-modality imaging final diagnoses to evaluate the precise location, extent and morphology of myocardial abscess (MA) was done. "On pump" coronary artery bypass graft (CABG) was performed, left anterior descending (LAD) artery intramyocardially was opened up, about 7-10 ml of pus was evacuated, and two drug-eluting stents (DES) were removed. The isolated identified organism was Pseudomonas aeruginosa which had remained dormant and restricted to the stent area for almost 2 years thinning the myocardium; an unusual trait of a very virulent bacterium which otherwise spreads fast to cause septicemia. The present case exemplifies the high index of clinical sensitivity with early multi-modality diagnosis, aggressive medical therapy, multidisciplinary care, and timely surgical intervention saving the patient's life in otherwise fatal condition.

摘要

经皮腔内冠状动脉成形术(PTCA)联合药物洗脱支架置入是治疗冠状动脉狭窄病变的一种成熟治疗方式。虽然植入支架相关感染罕见,但可在任何时间发生,导致高发病率和死亡率。我们描述了1例罕见的感染性冠状动脉支架病例,在经皮冠状动脉介入治疗(PCI)2年后并发复发性支架血栓形成、脓毒症和心肌脓肿形成。采用多模态成像对心肌脓肿(MA)的精确位置、范围和形态进行了最终诊断。进行了“体外循环下”冠状动脉旁路移植术(CABG),打开左前降支(LAD)动脉的心内膜,排出约7 - 10毫升脓液,并取出2个药物洗脱支架(DES)。分离鉴定出的病原体是铜绿假单胞菌,它在支架区域潜伏了近2年,使心肌变薄;这是一种毒性很强的细菌的不寻常特征,否则它会迅速扩散导致败血症。本病例体现了早期多模态诊断、积极的药物治疗、多学科护理以及及时的手术干预所具有的高临床敏感性,从而在原本致命的情况下挽救了患者的生命。

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本文引用的文献

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Pseudomonas aeruginosa coronary stent infection.
Ann Thorac Surg. 1997 Dec;64(6):1810-3. doi: 10.1016/s0003-4975(97)01151-x.
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Diagnostic evaluation of myocardial abscesses. A new look at an old problem.
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