Jindahra Panitha, Hengsiri Nitchanan, Witoonpanich Pirada, Poonyathalang Anuchit, Pulkes Teeratorn, Tunlayadechanont Supoch, Thadanipon Kunlawat, Vanikieti Kavin
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clin Ophthalmol. 2020 Oct 2;14:2995-3000. doi: 10.2147/OPTH.S276625. eCollection 2020.
To evaluate the feasibility of using optical coherence tomography (OCT) for the detection of Alzheimer's disease (AD), by measuring the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer and inner plexiform layer (GCL-IPL).
This was a single-center, cross-sectional study. The study included 29 patients with AD (mean age ± standard deviation: 75.61 ± 6.24 years) and 29 healthy age- and sex-matched controls. All participants underwent cognitive evaluations using the Montreal Cognitive Assessment test. Measurements of the RNFL thickness, as well as GCL-IPL thickness, were obtained for all participants using OCT. Both RNFL and GCL-IPL parameters were adjusted for best-corrected visual acuity, hypertension, diabetes and dyslipidemia.
The mean RNFL thickness was significantly thinner in the AD group than in the control group (85.24 and 90.68 µm, respectively, adjusted P=0.014). The superior quadrant was thinner in the AD group (adjusted P=0.033). The thicknesses did not differ significantly between groups for the other quadrants. The mean GCL-IPL thickness in the AD (68.81 µm) was significantly thinner than that in the controls (76.42 µm) (adjusted P=0.014). Overall, there was a negative correlation between age and mean RNFL; and between age and GCL-IPL thickness (r=-0.338, P=0.010 and r=-0.346, P=0.008, respectively).
The mean RNFL and GCL-IPL thicknesses were thinner in the AD group than in the control group. These findings suggest that RNFL and GCL-IPL thickness may be biological markers for AD.
通过测量视网膜神经纤维层（RNFL）以及神经节细胞层和内丛状层（GCL - IPL）的厚度，评估光学相干断层扫描（OCT）用于检测阿尔茨海默病（AD）的可行性。
这是一项单中心横断面研究。该研究纳入了29例AD患者（平均年龄±标准差：75.61±6.24岁）以及29例年龄和性别匹配的健康对照者。所有参与者均使用蒙特利尔认知评估测试进行认知评估。使用OCT测量所有参与者的RNFL厚度以及GCL - IPL厚度。对RNFL和GCL - IPL参数均针对最佳矫正视力、高血压、糖尿病和血脂异常进行了校正。
AD组的平均RNFL厚度显著薄于对照组（分别为85.24和90.68µm，校正后P = 0.014）。AD组的上象限更薄（校正后P = 0.033）。其他象限的厚度在两组之间无显著差异。AD组的平均GCL - IPL厚度（68.81µm）显著薄于对照组（76.42µm）（校正后P = 0.014）。总体而言，年龄与平均RNFL之间以及年龄与GCL - IPL厚度之间存在负相关（r分别为 - 0.338，P = 0.010和r = - 0.346，P = 0.008）。
AD组的平均RNFL和GCL - IPL厚度薄于对照组。这些发现表明RNFL和GCL - IPL厚度可能是AD的生物学标志物。
