Rasouli Esmat, Sadeghi Narges, Parsi Abazar, Hashemi Seyed Jalal, Nayebi Morteza, Shayesteh Aliakbar
Alimentary Tract Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Clin Exp Gastroenterol. 2020 Oct 2;13:419-425. doi: 10.2147/CEG.S254278. eCollection 2020.
Previous studies have shown that vitamin D plays an important role in inflammatory bowel disease (IBD). This study was designed to investigate the relationship between vitamin D levels and disease activity in IBD patients in Ahvaz, Iran.
This cross-sectional study was conducted on adult IBD patients referring to the outpatient clinic of gastroenterology at Imam Khomeini Hospital in Ahvaz city, in the southwest of Iran. Each patient's disease activity defined according to Crohn's disease activity index (CDAI) in Crohn's disease (CD) and Truelove score in ulcerative colitis (UC) patients, serum 25[OH]D was measured using the radioimmunoassay method. Vitamin D deficiency was defined as concentration of <20 nmol/L.
Studied subjects were 130 UC and 23 CD patients (62.1% females) with a mean age of 37.5 ± 12.35 years. Vitamin D deficiency was present in 99 (64.7%) IBD patients. Fifty-three patients (34.6%) had active disease who, compared with patients in remission, had more frequent low vitamin D levels (80 vs 56.7%, = 0.017). In UC patients, disease activity was significantly associated with vitamin D deficiency ( = 0.035), but no such relationship was observed in CD patients ( = 0.74).
Vitamin D deficiency was significantly associated with disease activity in IBD, especially in UC patients. Therefore, careful monitoring of vitamin D deficiency in these patients is highly recommended. Prospective cohort studies are also needed to determine the role of vitamin D deficiency and its treatment in the clinical course of IBD.
既往研究表明维生素D在炎症性肠病（IBD）中起重要作用。本研究旨在调查伊朗阿瓦士IBD患者维生素D水平与疾病活动度之间的关系。
本横断面研究针对转诊至伊朗西南部阿瓦士市伊玛目霍梅尼医院胃肠病门诊的成年IBD患者开展。根据克罗恩病活动指数（CDAI）确定克罗恩病（CD）患者的疾病活动度，根据TrueLove评分确定溃疡性结肠炎（UC）患者的疾病活动度，采用放射免疫分析法测定血清25[OH]D。维生素D缺乏定义为浓度<20 nmol/L。
研究对象为130例UC患者和23例CD患者（62.1%为女性），平均年龄37.5±12.35岁。99例（64.7%）IBD患者存在维生素D缺乏。53例（34.6%）患者处于疾病活动期，与缓解期患者相比，维生素D水平低的情况更常见（80%对56.7%，P = 0.017）。在UC患者中，疾病活动度与维生素D缺乏显著相关（P = 0.035），但在CD患者中未观察到这种关系（P = 0.74）。
维生素D缺乏与IBD的疾病活动度显著相关，尤其是在UC患者中。因此，强烈建议对这些患者的维生素D缺乏情况进行仔细监测。还需要进行前瞻性队列研究以确定维生素D缺乏及其治疗在IBD临床病程中的作用。
