Wu Zengrong, Liu Deliang, Deng Feihong
Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People's Republic of China.
Research Center of Digestive Disease, Central South University, Changsha, Hunan, 410011, People's Republic of China.
J Inflamm Res. 2022 May 28;15:3167-3185. doi: 10.2147/JIR.S363840. eCollection 2022.
Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn's disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.
炎症性肠病（IBD）是一种非特异性炎症性疾病，包括溃疡性结肠炎（UC）和克罗恩病（CD）。IBD的发病机制尚未完全明确，但多数报道认为其与免疫失调、肠道菌群失调、遗传易感性和环境风险因素有关。维生素D是人体必需的营养素，它不仅调节骨代谢，还调节免疫系统、肠道微生物群和肠道屏障。维生素D缺乏在IBD患者中很常见，维生素D异常低水平与IBD的疾病活动、治疗反应及复发风险高度相关。越来越多的证据支持维生素D通过调节适应性免疫和固有免疫、维持肠道屏障及平衡肠道微生物群在IBD中发挥保护作用。本报告旨在全面概述维生素D在免疫系统中的作用，尤其是在IBD的发病机制和治疗中的作用，以及其在预测复发方面的可能作用。
