一种基因变体降低中国人群患胃癌风险：一项病例对照研究的证据
A Variant of Gene Decreases the Risk of Gastric Cancer in Chinese Individuals: Evidence from a Case-Control Study.
作者信息
Ma Renjie, He Qi
机构信息
Department of Infectious Disease, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, Jiangsu Province, 212300, People's Republic of China.
出版信息
Pharmgenomics Pers Med. 2020 Sep 22;13:397-404. doi: 10.2147/PGPM.S258672. eCollection 2020.
BACKGROUND
A host of studies have explored the potential connection between () G19A polymorphism and the risk of cancers, but the relationship between gastric cancer (GC) susceptibility and G19A polymorphism was not revealed before. The aim of this study was to investigate this relationship in Chinese Han population.
METHODS
Thus, this case-control study with 380 GC cases and 465 controls was designed to unearth the link between G19A polymorphism and GC susceptibility. Genotyping was accomplished by a custom-made 48-Plex SNP scanTM kit. Relative gene expression was detected by real-time reverse transcription-polymerase chain reaction.
RESULTS
G19A polymorphism was shown to relate with a decreased risk of GC. Subgroup analyses uncovered significant connections in the males, nondrinkers, and those at age <60 years. G19A polymorphism was also linked with tumor size and location and pathological type of GC. Last, gene expression in gastric tissues was considerably less than in control tissues.
CONCLUSION
This study shows that G19A polymorphism of gene is linked with a lower risk of GC in the tested Chinese Han individuals.
背景
大量研究探讨了（）G19A多态性与癌症风险之间的潜在联系，但此前未揭示胃癌（GC）易感性与G19A多态性之间的关系。本研究的目的是在中国汉族人群中调查这种关系。
方法
因此，本病例对照研究纳入380例GC患者和465例对照，旨在揭示G19A多态性与GC易感性之间的联系。基因分型通过定制的48重SNP扫描TM试剂盒完成。通过实时逆转录聚合酶链反应检测相关基因表达。
结果
G19A多态性与GC风险降低相关。亚组分析发现，在男性、不饮酒者和年龄<60岁的人群中存在显著关联。G19A多态性还与GC的肿瘤大小、位置和病理类型有关。最后，胃组织中的基因表达明显低于对照组织。
结论
本研究表明，在受试中国汉族个体中，基因的G19A多态性与GC风险较低有关。
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