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成功通过内镜切断术治疗一名患有痴笑性癫痫儿童的下丘脑错构瘤:资源稀缺环境下的一个罕见病例

Successful Endoscopic Disconnection for Hypothalamic Hamartomas in a Child with Gelastic Seizures: An Unusual Case in a Resource-Scare Setting.

作者信息

Dong He Van, Tran Van Dinh, Nguyen Dinh-Hoa, Vu Hoe Van, Nguyen Tuan Anh, Doan Ha Ngoc Thi, Vo Hoang-Long

机构信息

Department of Neurosurgery I, Viet Duc University Hospital, Hanoi 100000, Vietnam.

Institute of Orthopedic Trauma, Viet Duc University Hospital, Hanoi 100000, Vietnam.

出版信息

Int Med Case Rep J. 2020 Sep 14;13:425-429. doi: 10.2147/IMCRJ.S265810. eCollection 2020.

Abstract

Although the endoscopic disconnection surgery for the hamartomas was previously shown as a safe and effective treatment strategy in eliminating gelastic epilepsy, to date, there was no convincing evidence with this procedure in the resource-scare settings. We discuss an unusual case of a 7-year-old child who suffered from pharmacoresistant gelastic seizures was surgically treated with the endoscopic disconnection of the hypothalamic hamartomas. The patient underwent endoscopic surgery through the left ventricle approach to disconnect the lesion of the hypothalamus. Immediately after surgery, the patient's clinical laughter was eliminated with no complications. From the initial experience at our center, successful outcome of this case contributes to supporting the solid evidence in choosing the right treatment approach for the hypothalamus in subsequent cases, towards not only Vietnam but also the countries having similar resource-scare conditions.

摘要

尽管先前已表明,针对错构瘤的内镜下离断手术是消除痴笑性癫痫的一种安全有效的治疗策略,但迄今为止,在资源匮乏的环境中,尚无关于该手术的确凿证据。我们讨论了一例特殊病例,一名7岁患有药物难治性痴笑性癫痫的儿童接受了下丘脑错构瘤的内镜下离断手术治疗。患者通过左心室入路接受了内镜手术,以离断下丘脑病变。术后患者的临床痴笑立即消失,且无并发症。根据我们中心的初步经验,该病例的成功结果有助于为后续病例选择正确的下丘脑治疗方法提供有力证据,不仅适用于越南,也适用于具有类似资源匮乏状况的国家。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b86/7519339/067ce5c11d79/IMCRJ-13-425-g0001.jpg

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