Pujol J P, Loyau G
Life Sci. 1987 Sep 7;41(10):1187-98. doi: 10.1016/0024-3205(87)90196-2.
Il-1, a multifunctional monokine, can stimulate both synoviocytes and articular chondrocytes to release neutral proteases and prostaglandin E2. It is also capable of promoting bone resorption. Therefore, this molecule (or family of molecules) is likely to play an important role in the mechanism of articular cartilage destruction that occurs in degenerative arthropathies. The synovial tissue itself can produce Il-1 (Catabolin) in some conditions, such as a slight traumatism, so that the presence of local inflammation is not necessary for "Il-1-cartilage" interaction to occur. Fundamental macromolecules of cartilage (collagens, proteoglycans) exert a stimulatory effect on Il-1 production, either as such or in the form of immune complexes. Some activated complement fractions (C3a and C5a) may also be actively involved. Studies on the mechanisms which regulate Il-1 synthesis and release, as well as investigations on the response of target cells to Il-1, are presently fascinating goals that could lead to new strategies in therapeutic research.
白细胞介素-1是一种多功能单核因子，能刺激滑膜细胞和关节软骨细胞释放中性蛋白酶和前列腺素E2。它还能够促进骨吸收。因此，这种分子（或分子家族）可能在退行性关节病中发生的关节软骨破坏机制中起重要作用。滑膜组织本身在某些情况下，如轻微创伤时，能够产生白细胞介素-1（分解素），所以“白细胞介素-1 - 软骨”相互作用的发生并不需要局部炎症的存在。软骨的基本大分子（胶原蛋白、蛋白聚糖）本身或以免疫复合物的形式对白细胞介素-1的产生发挥刺激作用。一些活化的补体成分（C3a和C5a）也可能积极参与其中。目前，关于调节白细胞介素-1合成和释放机制的研究以及对靶细胞对白细胞介素-1反应的研究，是极具吸引力的目标，可能会带来治疗研究的新策略。
