Sheikh Shafain, Jahangir Sehreen, Khan Samreen, Ahmed Imran
Immunology, Shifa International Hospital, Islamabad, PAK.
Hematology, Shifa International Hospital, Islamabad, PAK.
Cureus. 2020 Sep 10;12(9):e10353. doi: 10.7759/cureus.10353.
Chronic lymphoproliferative disorders are a diverse group of diseases derived from thymus lymphocytes (T cells), bursa of Fabricius cells (B cells), or natural killer (NK) cells. The diagnosis of chronic lymphoproliferative disorders of NK cells (CLPD-NK) is confirmed using antibody panels that are able to detect various stages of maturation of malignant cells. Autoimmune diseases and viral infections are often associated with an increase in circulating NK cells. It is hypothesized that certain viruses trigger the activation of NK cells which leads to the formation of NK cell clones. Majority of the cases are asymptomatic. However, some patients have systemic symptoms and cytopenias. Here, we report a case of CLPD-NK. Our patient's history and marked lymphocytosis on peripheral film raised the suspicion of a hematolymphoid malignancy for which flow cytometric analysis was done using an extensive panel which confirmed the diagnosis of CLPD-NK.
慢性淋巴细胞增殖性疾病是一组源自胸腺淋巴细胞（T细胞）、法氏囊细胞（B细胞）或自然杀伤（NK）细胞的多种疾病。使用能够检测恶性细胞成熟各个阶段的抗体组合来确诊自然杀伤细胞慢性淋巴细胞增殖性疾病（CLPD-NK）。自身免疫性疾病和病毒感染常与循环NK细胞增多有关。据推测，某些病毒触发NK细胞的活化，从而导致NK细胞克隆的形成。大多数病例无症状。然而，一些患者有全身症状和血细胞减少。在此，我们报告一例CLPD-NK病例。我们患者的病史及外周血涂片上显著的淋巴细胞增多引起了对血液淋巴系统恶性肿瘤的怀疑，为此使用广泛的抗体组合进行了流式细胞术分析，确诊为CLPD-NK。
