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退伍军人事务部急诊科和牙科诊所实施阿片类药物处方指南前后的阿片类药物处方趋势

Opioid prescribing trends in a Veterans Affairs emergency department and dental clinic before and after implementation of opioid-prescribing guidelines.

作者信息

Lavasani Rebecca, Chung Michelle, Beatty Allison, Lawrence Phillip, Unni Elizabeth

机构信息

Clinical Pharmacist, Veterans Affairs Sierra Nevada Health Care System, Reno, Nevada,

Postgraduate Year 1 Pharmacy Resident, Kadlec Regional Medical Center, Richland, Washington.

出版信息

Ment Health Clin. 2020 Sep 30;10(5):270-274. doi: 10.9740/mhc.2020.09.270. eCollection 2020 Sep.

Abstract

INTRODUCTION

Opioid overdose is highly prevalent among veterans. The Opioid Safety Initiative (OSI) and Centers for Disease Control and Prevention (CDC) issued prescribing guidelines for managing chronic pain. The purpose of this study was to investigate the impact of the 2013 OSI and 2016 CDC guidelines on opioid-prescribing trends in the emergency department and dental clinic within the Veterans Affairs Salt Lake City Health Care System.

METHODS

In this retrospective, cohort study, opioid prescriptions were queried from January 1, 2013, through March 31, 2017, and separated into 3 groups: pre-OSI, post-OSI, and post-CDC. The primary outcome was to determine a decrease in opioid prescribing. Secondary outcomes included changes in concurrent benzodiazepine and naloxone prescriptions and prescriber status. Analysis of variance was used to determine a difference between study periods.

RESULTS

There were 7339 opioid prescriptions identified. A statistically significant difference was found between the 3 groups in average number of opioids prescribed, morphine milligram equivalents per prescription, days' supplied, and medication quantity per prescription ( < .01). There was no significant difference between the 3 groups regarding morphine milligram equivalents per day ( = .24). Benzodiazepine prescribing remained the same. Concurrent naloxone prescriptions increased.

DISCUSSION

The results demonstrate that days' supply, quantity, and morphine milligram equivalent per day in the post-CDC group were consistent with guideline recommendations. Concurrent naloxone prescribing increased throughout all time periods. Implementation of guidelines impacted opioid-prescribing trends, ultimately lessening potential for misuse and abuse. However, there is still need for improvement with reducing concurrent benzodiazepine prescriptions.

摘要

引言

阿片类药物过量在退伍军人中极为普遍。阿片类药物安全倡议(OSI)和疾病控制与预防中心(CDC)发布了管理慢性疼痛的处方指南。本研究的目的是调查2013年OSI指南和2016年CDC指南对盐湖城退伍军人事务医疗保健系统急诊科和牙科诊所阿片类药物处方趋势的影响。

方法

在这项回顾性队列研究中,查询了2013年1月1日至2017年3月31日期间的阿片类药物处方,并将其分为3组:OSI之前、OSI之后和CDC之后。主要结果是确定阿片类药物处方的减少情况。次要结果包括同时开具苯二氮卓类药物和纳洛酮处方的变化以及开处方者的状态。采用方差分析来确定研究期间之间的差异。

结果

共识别出7339份阿片类药物处方。在每组平均开具的阿片类药物数量、每张处方的吗啡毫克当量、供应天数和每张处方的药物数量方面,3组之间存在统计学上的显著差异(<0.01)。3组之间在每日吗啡毫克当量方面无显著差异(=0.24)。苯二氮卓类药物的处方量保持不变。同时开具纳洛酮的处方增加。

讨论

结果表明,CDC之后组的供应天数、数量和每日吗啡毫克当量与指南建议一致。在所有时间段内,同时开具纳洛酮的处方都有所增加。指南的实施影响了阿片类药物的处方趋势,最终降低了滥用和误用的可能性。然而,在减少同时开具苯二氮卓类药物处方方面仍有改进的必要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fa/7534812/7b06a841ba4a/i2168-9709-10-5-270-f01.jpg

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