Center for Life Science and Environmental Science, Harbin University of Commerce, Harbin 150076, China.
College of Life Sciences and Technology, Mudanjiang Normal University, Mudanjiang 157011, China.
Biomed Res Int. 2020 Oct 1;2020:7102046. doi: 10.1155/2020/7102046. eCollection 2020.
We successfully extracted isoliquiritigenin from through the utilization of an ionic liquid-based ultrasonic-assisted extraction (ILUAE) approach. Briefly, we utilized the solution of 1-butyl-3-methylimidazolium bromide ([BMIM]Br) as solvent and optimized key ILUAE parameters such as solid-liquid ratios, concentrations of ionic liquids, and the times of ultrasonication. Based on a single-factor experiment, we utilized the response surface method (RSM) approach to optimize the extraction procedure. The approach revealed that the optimal energy consumption time was 120 min, with the ultrasonic extraction temperature of 60°C. Using these optimized parameters together with the solid-liquid ratio (dried powder: [BMIM]Br of 0.3 mol/L) of 1 : 16.163 and the [BMIM]Br of 0.3 mol/L, we achieved a 0.665 mg/g extraction yield. Overall, these findings thus indicate that we were able to effectively use ILUAE as an efficient approach to reliably extract isoliquiritigenin in a reproducible and environmentally friendly manner.
我们成功地通过离子液体辅助超声提取（ILUAE）方法从甘草中提取了异甘草素。简要地说，我们使用 1-丁基-3-甲基咪唑溴盐([BMIM]Br)溶液作为溶剂，并优化了关键的 ILUAE 参数，如固液比、离子液体浓度和超声时间。基于单因素实验，我们利用响应面法（RSM）优化了提取过程。该方法表明，最佳能耗时间为 120 分钟，超声提取温度为 60°C。使用这些优化参数以及固液比（干燥的甘草粉：[BMIM]Br 为 0.3 mol/L）为 1:16.163 和 0.3 mol/L 的[BMIM]Br，我们实现了 0.665 mg/g 的提取收率。总体而言，这些发现表明我们能够有效地将 ILUAE 用作一种有效方法，以可靠、可重复和环保的方式提取异甘草素。
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