El-Alali Emran, Alhmoud Tarik
Department of Medicine, Anne Arundel Medical Center, Annapolis, MD.
Promedica Digestive Health Care (affiliated with ProMedica Toledo Hospital, Toledo, OH), Sylvania, OH.
ACG Case Rep J. 2020 Sep 29;7(9):e00459. doi: 10.14309/crj.0000000000000459. eCollection 2020 Sep.
Oral phenylephrine is a commonly used over-the-counter nasal decongestant drug. It is usually taken for symptomatic relief (in combination drug products) for upper respiratory tract infections, allergic rhinitis, or sinusitis. Adverse cardiovascular effects of intravenous phenylephrine, including organ ischemia, are well known; however, oral phenylephrine is rarely associated with significant adverse effects. We describe the first case of acute ischemic colitis in a young patient due to over-the-counter oral phenylephrine, which was taken as a nasal decongestant. We reviewed the literature of colonic ischemia related to the use of systemic nasal decongestants phenylephrine and pseudoephedrine.
口服去氧肾上腺素是一种常用的非处方鼻腔减充血剂药物。它通常用于缓解上呼吸道感染、过敏性鼻炎或鼻窦炎的症状（在复方药物产品中）。静脉注射去氧肾上腺素的不良心血管效应，包括器官缺血，是众所周知的；然而，口服去氧肾上腺素很少与严重不良反应相关。我们描述了首例因服用非处方口服去氧肾上腺素作为鼻腔减充血剂而导致年轻患者急性缺血性结肠炎的病例。我们回顾了与全身性鼻腔减充血剂去氧肾上腺素和伪麻黄碱使用相关的结肠缺血文献。
