Department of Microbiology, Institute of Biological Sciences, University of Rostock, Germany.
FEBS J. 2021 Mar;288(6):1804-1808. doi: 10.1111/febs.15575. Epub 2020 Oct 15.
In the human gut, plant dietary fibers are broken down to hexoses (C6) and pentoses (C5) and subsequently fermented by gut bacteria, producing short-chain fatty acids (SCFAs). The biochemistry of C5 metabolism has not been studied well in gut microorganisms. Garschagen et al. provide a new perspective in a detailed biochemical study on C5 metabolism of the abundant Prevotella copri, which uses the sedoheptulose-1,7-bisphosphate pathway instead of the pentose phosphate pathway.
在人类肠道中，植物膳食纤维被分解为六碳糖（C6）和五碳糖（C5），随后被肠道细菌发酵，产生短链脂肪酸（SCFAs）。C5 代谢在肠道微生物中的生物化学尚未得到很好的研究。Garschagen 等人在对丰富的Prevotella copri 的 C5 代谢的详细生化研究中提供了一个新的视角，该菌使用 sedoheptulose-1,7-bisphosphate 途径而不是戊糖磷酸途径。
