军人服役史与癌症诊断之间是否存在关联？一项基于自我报告结局的美国全国性研究结果。

Is there an association between a history of military service and cancer diagnosis? Results from a US national-level study of self-reported outcomes.

机构信息

Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada.

出版信息

Cancer Causes Control. 2021 Jan;32(1):47-55. doi: 10.1007/s10552-020-01355-4. Epub 2020 Oct 16.

DOI:10.1007/s10552-020-01355-4

PMID:33064242

Abstract

PURPOSE

To examine cancer prevalence in men with and without military service history, using national-level self-reported outcomes.

METHODS

A cross-sectional survey-based US study, including men aged 18 and above from the Health Information National Trends Survey database between 2011 and 2014. The primary endpoint was self-reported cancer prevalence. Multivariable logistic regression analyses assessed the association of various covariates with the prevalence of cancer.

RESULTS

A total of 4,527 men were analyzed, with 1,352 (29.9%) reporting a history of military service. Compared to men with no military service history, men with a military service history were older (median of 65 [IQR 56, 74] vs. 53 [IQR 41, 62] years, p < 0.0001), more commonly Caucasian (71.4% vs. 61.4%, p < 0.0001), born in the US (95.6% vs. 79.5%, p < 0.0001), attained higher education level and annual household income (p < 0.0001), and consisted of more smokers(58.3% vs. 44.5%, p < 0.0001). The age-adjusted comparison demonstrated a higher cancer prevalence in men with military service history (20.5% vs. 7.6%, p < 0.0001). Specifically, genitourinary, dermatological, gastrointestinal, and hematological cancers were generally more prevalent. Adjusting for all available confounders, multivariable models showed that military service history was associated with 1.56 (95% CI 1.20-2.03), and 1.57 (95% CI 1.07-2.31) increased odds of having any cancer, and specifically genitourinary cancer, respectively.

CONCLUSIONS

Further research is needed to ascertain whether the association between military service and increased cancer diagnosis results from better screening programs or increased exposure to risk factors during military service.

摘要

目的

使用全国范围内的自我报告结果，研究有和没有兵役史的男性癌症患病率。

方法

这是一项基于横断面调查的美国研究，纳入了 2011 年至 2014 年期间健康信息国家趋势调查数据库中年龄在 18 岁及以上的男性。主要终点是自我报告的癌症患病率。多变量逻辑回归分析评估了各种协变量与癌症患病率的关系。

结果

共分析了 4527 名男性，其中 1352 名（29.9%）有兵役史。与没有兵役史的男性相比，有兵役史的男性年龄更大（中位数 65 [IQR 56，74] 岁 vs. 53 [IQR 41，62] 岁，p<0.0001），更常见白人（71.4% vs. 61.4%，p<0.0001），出生于美国（95.6% vs. 79.5%，p<0.0001），受教育程度和家庭年收入更高（p<0.0001），吸烟者更多（58.3% vs. 44.5%，p<0.0001）。年龄调整后的比较显示，有兵役史的男性癌症患病率更高（20.5% vs. 7.6%，p<0.0001）。具体而言，泌尿生殖系统、皮肤科、胃肠道和血液系统癌症更为常见。调整所有可用的混杂因素后，多变量模型显示兵役史与任何癌症的患病风险增加 1.56（95% CI 1.20-2.03）和 1.57（95% CI 1.07-2.31）有关，分别为增加的几率，以及特定的泌尿生殖系统癌症。