Luo Yizhou, Pang Cui
Department of Medical Oncology, The Air Force Hospital of Eastern Theater, Anhui Medical University, Nanjing, China.
Department of Medical Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Medicine (Baltimore). 2025 Sep 5;104(36):e44171. doi: 10.1097/MD.0000000000044171.
Military service presents a paradoxical health impact, simultaneously enhancing physical fitness while increasing risks of injuries, mental health disorders, and war-related illnesses. The long-term mortality consequences for aging veterans remain insufficiently characterized. This study examines the association between military service and mortality outcomes among US adults aged 50 years and older, including all-cause mortality, premature death, and cause-specific mortality. We analyzed 17,984 participants from the National Health and Nutrition Examination Survey (1999-2018) with complete data on military service status and mortality outcomes. Using weighted multivariate modeling, Kaplan-Meier survival analyses, and subgroup analyses, we evaluated mortality risks while adjusting for demographic, socioeconomic, and health covariates (gender, age, ethnicity, education, marital status, income, diabetes, and hypertension). During 250 months of follow-up (3985 deaths), veterans showed longer mean survival time (139.36 ± 1.38 months) than nonveterans (129.66 ± 1.43 months). In fully adjusted models, military service was positively associated with survival time (β = 21.87, 95% confidence interval [CI] = 17.03-26.70, P < .001). However, non-veterans demonstrated reduced risks for premature mortality (odds ratio = 0.69, 95% CI = 0.58-0.82, P < .001), malignancy-related deaths (odds ratio = 0.73, 95% CI = 0.55-0.96, P = .025), and other cause-specific mortality compared to veterans. While military service is associated with longer overall survival in older adults, it confers increased risks of premature death and cancer mortality. These findings highlight the need for targeted health interventions for aging veterans, particularly for cancer prevention and early detection.
军事服役对健康有着矛盾的影响,它在增强身体素质的同时,也增加了受伤、心理健康障碍以及与战争相关疾病的风险。对于老年退伍军人的长期死亡后果,目前仍缺乏充分的描述。本研究调查了50岁及以上美国成年人的军事服役与死亡结果之间的关联,包括全因死亡率、过早死亡和特定原因死亡率。我们分析了来自国家健康与营养检查调查(1999 - 2018年)的17984名参与者,他们拥有关于军事服役状况和死亡结果的完整数据。通过加权多变量建模、Kaplan - Meier生存分析和亚组分析,我们在调整了人口统计学、社会经济和健康协变量(性别、年龄、种族、教育程度、婚姻状况、收入、糖尿病和高血压)后评估了死亡风险。在250个月的随访期间(3985人死亡),退伍军人的平均生存时间(139.36 ± 1.38个月)比非退伍军人(129.66 ± 1.43个月)更长。在完全调整模型中,军事服役与生存时间呈正相关(β = 21.87,95%置信区间[CI] = 17.03 - 26.70,P <.001)。然而,与退伍军人相比,非退伍军人过早死亡风险降低(优势比 = 0.69,95% CI = 0.58 - 0.82,P <.001),恶性肿瘤相关死亡风险降低(优势比 = 0.73,95% CI = 0.55 - 0.96,P =.025),以及其他特定原因死亡率降低。虽然军事服役与老年人总体生存时间延长有关,但它也带来了更高的过早死亡和癌症死亡风险。这些发现凸显了针对老年退伍军人进行有针对性的健康干预的必要性,特别是在癌症预防和早期检测方面。