Ettinger W H, Bender W L, Goldberg A P, Hazzard W R
Nephron. 1987;47(1):17-21. doi: 10.1159/000184450.
There is disagreement about the prevalence and character of lipoprotein lipid abnormalities in renal transplant patients. To test the hypothesis that these abnormalities may be related to the coexistence of medical conditions and medications which affect lipoprotein metabolism in these patients, triglyceride (TG), cholesterol (C), high-density lipoprotein (HDL) and HDL-C subfractions were measured in 26 transplanted patients (10 F/16 M), control subjects matched for age, sex, weight and race and uremic patients being treated with hemodialysis. Female transplant recipients had higher TG (181 +/- 47 vs. 68 +/- 6 mg/dl; p less than 0.001), C (242 +/- 19 vs. 165 +/- 9 mg/dl; p less than 0.01), and low-density lipoprotein (LDL)-C (155 +/- 15 vs. 93 +/- 8 mg/dl; p less than 0.01) than controls. Levels of HDL-C were similar, but HDL2 was significantly lower in the transplanted patients (9 +/- 2 vs. 19 +/- 2 mg/dl; p less than 0.01). Compared to the uremic patients, female transplanted patients had higher C (242 +/- 19 vs. 178 +/- 22 mg/dl; p less than 0.01), LDL-C (155 +/- 15 vs. 94 +/- 18 mg/dl; p less than 0.01), HDL-C (51 +/- 5 vs. 32 +/- 4 mg/dl; p less than 0.001) and HDL3-C (42 +/- 4 vs. 26 +/- 2 mg/dl; p less than 0.001); however, HDL2-C levels were not significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)
对于肾移植患者脂蛋白脂质异常的患病率和特征存在不同意见。为了验证这些异常可能与影响这些患者脂蛋白代谢的内科疾病和药物共存有关这一假设，对26例移植患者（10名女性/16名男性）、年龄、性别、体重和种族相匹配的对照受试者以及接受血液透析治疗的尿毒症患者进行了甘油三酯（TG）、胆固醇（C）、高密度脂蛋白（HDL）和HDL-C亚组分的测量。女性移植受者的TG（181±47 vs. 68±6 mg/dl；p<0.001）、C（242±19 vs. 165±9 mg/dl；p<0.01）和低密度脂蛋白（LDL）-C（155±15 vs. 93±8 mg/dl；p<0.01）高于对照组。HDL-C水平相似，但移植患者的HDL2显著较低（9±2 vs. 19±2 mg/dl；p<0.01）。与尿毒症患者相比，女性移植患者的C（242±19 vs. 178±22 mg/dl；p<0.01）、LDL-C（155±15 vs. 94±18 mg/dl；p<0.01）、HDL-C（51±5 vs. 32±4 mg/dl；p<0.001）和HDL3-C（42±4 vs. 26±2 mg/dl；p<0.001）更高；然而，HDL2-C水平没有显著差异。（摘要截断于250字）
