Gibson G E, Peterson C
Neurobiol Aging. 1987 Jul-Aug;8(4):329-43. doi: 10.1016/0197-4580(87)90072-8.
Many aspects of calcium homeostasis change with aging. Numerous calcium compartments complicate studies of altered calcium regulation. However, age-related decreases in calcium permeation across membranes and mobilization from organelles may be a common fundamental change. Deficits in ion movements appear to lead to altered coupling of calcium-dependent biochemical and neurophysiological processes and may lead to pathological and behavioral changes. The calcium-associated changes during aging probably do not occur with equal intensity in all cell types or in different parts of the same cell. Thus, cells or compartments with a high proportion of calcium activated processes would be more sensitive to diminished calcium availability. These age-related changes may predispose the brain to the development of age-related neurological disorders. The effects of decreased ion movement may be further aggravated by an age-related decline in other calcium-dependent processes. Depression of some of these calcium-dependent functions appears physiologically significant, since increasing calcium availability ameliorates age-related deficits in neurotransmission and behavior. A better understanding of the interactions between calcium homeostasis and calcium-dependent processes during aging will likely help in the design of more effective therapeutic strategies.
钙稳态的许多方面会随着衰老而发生变化。众多的钙区室使钙调节改变的研究变得复杂。然而，与年龄相关的跨膜钙渗透和细胞器钙动员的减少可能是一个共同的基本变化。离子运动的缺陷似乎会导致钙依赖的生化和神经生理过程的耦合改变，并可能导致病理和行为变化。衰老过程中与钙相关的变化在所有细胞类型或同一细胞的不同部位可能不会以相同强度发生。因此，具有高比例钙激活过程的细胞或区室对钙可用性降低会更敏感。这些与年龄相关的变化可能使大脑更容易患上与年龄相关的神经疾病。离子运动减少的影响可能会因其他钙依赖过程与年龄相关的下降而进一步加剧。其中一些钙依赖功能的抑制在生理上似乎具有重要意义，因为增加钙可用性可改善与年龄相关的神经传递和行为缺陷。更好地理解衰老过程中钙稳态与钙依赖过程之间的相互作用可能有助于设计更有效的治疗策略。
