Triangulation Sensing to Determine the Gradient Source from Diffusing Particles to Small Cell Receptors.

How does a cell locate the source of molecular guidance cues from within a concentration gradient? We present a computational approach to recover the source from the absorbed fluxes at narrow receptor windows located on the surface of the cell. In the limit of fast binding, we solve the steady-state diffusion equation using an asymptotic approach and hybrid stochastic-analytical simulations. We show that the sensitivity to the gradient direction decays too rapidly to enable long-distance sensing. We illustrate how this constraint can be alleviated when triangulating the source with an increasing number of receptor windows and quantify the susceptibility of this process to flux perturbations.