Department of Global Health, University of Washington, Seattle, Washington, USA.
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
J Infect Dis. 2021 Jun 4;223(11):1923-1927. doi: 10.1093/infdis/jiaa640.
Identifying determinants of human immunodeficiency virus (HIV) reservoir levels may inform novel viral eradication strategies. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) coinfections were assessed as predictors of HIV proviral DNA level in 26 HIV RNA-suppressed Kenyan children starting antiretroviral therapy before 7 months of age. Earlier acquisition of CMV and EBV and higher cumulative burden of systemic EBV DNA viremia were each associated with higher HIV DNA level in the reservoir after 24 months of antiretroviral therapy, independent of HIV RNA levels over time. These data suggest that delaying or containing CMV and EBV viremia may be novel strategies to limit HIV reservoir formation.
确定人类免疫缺陷病毒 (HIV) 储存库水平的决定因素可能为新的病毒清除策略提供信息。在 7 个月大之前开始抗逆转录病毒治疗的 26 名肯尼亚儿童中，评估巨细胞病毒 (CMV) 和 Epstein-Barr 病毒 (EBV) 合并感染作为 HIV 前病毒 DNA 水平的预测因子。在抗逆转录病毒治疗 24 个月后，CMV 和 EBV 的更早获得以及全身性 EBV DNA 病毒血症的累积负担更高，与 HIV RNA 水平随时间变化无关，与储库中 HIV DNA 水平更高相关。这些数据表明，延迟或控制 CMV 和 EBV 病毒血症可能是限制 HIV 储存库形成的新策略。
