Saint James School of Medicine.
KEAN University, College of Natural, Applied and Health Sciences, Union, NJ, USA. Saint James School of Medicine, Basic Medical Sciences, Park Ridge, IL USA.
J Pharm Pharm Sci. 2020;23. doi: 10.18433/jpps30967.
We aimed to comprehensively evaluate the effects of medical marijuana on symptoms that are relevant to movement disorders with a focus on Huntington disease (HD).
A systematic review by literature search through PubMed and EBSCO electronic databases was conducted for relevant studies reported after 2002 on the effects of medical marijuana or cannabis use on tremor, spasm, spasticity, chorea, sleep quality and HD-specific rating scales. Study selection, quality assessment and data extraction was performed by three reviewers. Outcome measures were changes in psychomotor, and sleep related symptoms. The methodological quality of the included studies was evaluated. Results: A total of 22 studies were reviewed. There was strong evidence for significant improvement in the neurologic symptoms of spasms, tremors, spasticity, chorea, and quality of sleep following treatment with medical marijuana. Analysis of specific motor symptoms revealed significant improvement after treatment in tremors and rigidity. Furthermore, all pretreatment and post-treatment measures indicated a significant increase in average number of hours slept.
Larger scale studies are warranted to test the benefits of medical marijuana in HD patients. In the meanwhile, clinicians may consider prescribing medical marijuana as part of their strategy for better symptomatic treatment of patients with HD.
我们旨在全面评估医用大麻对运动障碍相关症状的影响，重点关注亨廷顿病（HD）。
通过 PubMed 和 EBSCO 电子数据库进行系统的文献检索，对 2002 年后报道的关于医用大麻或大麻使用对震颤、痉挛、痉挛、舞蹈病、睡眠质量和 HD 特定评定量表影响的相关研究进行综合评价。由三名评审员进行研究选择、质量评估和数据提取。结果衡量标准为精神运动和睡眠相关症状的变化。评估了纳入研究的方法学质量。
共审查了 22 项研究。有强有力的证据表明，医用大麻治疗可显著改善痉挛、震颤、痉挛、舞蹈病和睡眠质量等神经系统症状。对特定运动症状的分析表明，治疗后震颤和僵直有显著改善。此外，所有治疗前后的测量都表明平均睡眠时间显著增加。
需要更大规模的研究来测试医用大麻在 HD 患者中的益处。与此同时，临床医生可以考虑将医用大麻作为其治疗 HD 患者症状的策略的一部分。
