Jin Mingming, Shi Nannan, Wang Meng, Shi Chunzi, Lu Shengjie, Chang Qing, Sha Shuang, Lin Yun, Chen Yingmin, Zhou Hui, Liang Kaiyi, Huang Xuyuan, Shi Yuxin, Huang Gang
Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Aging (Albany NY). 2020 Oct 16;12(20):19867-19879. doi: 10.18632/aging.103941.
The ongoing outbreak of COVID-19 has been announced by the World Health Organization as a worldwide public health emergency. The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients. The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The cut-off value for CD45 was -94.33. The K-values for CD45 in non-severe case were above the cut-off values, indicating a 100% prediction success rate for severe and non-severe cases following SARS-CoV-2 infection. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly for the elderly. CD45 deficiency dysfunction the naïve and memory T lymphocytes which may affects the long-term effectiveness of COVID-19 vaccines. K-values of CD45 might be useful in distinguishing between severe and non-severe cases in the early infection. May be CD45 could increase the diagnostic sensitivity.
世界卫生组织已宣布持续爆发的新冠病毒病（COVID-19）为全球突发公共卫生事件。本研究的目的是在早期诊断中区分重症和非重症患者。结果显示，COVID-19患者的死亡率随年龄增长而增加。重症肺炎患者的宿主因素CRP、IL-1β、hs-CRP、IL-8和IL-6水平高于非重症患者。COVID-19患者的CD3、CD8和CD45计数降低。本研究结果表明，CD45的K值可能有助于区分重症和非重症病例。CD45的截断值为-94.33。非重症病例中CD45的K值高于截断值，表明在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后，重症和非重症病例的预测成功率为100%。结果证实，免疫系统功能障碍是COVID-19感染后死亡的潜在原因，尤其是对老年人而言。CD45缺乏会使初始和记忆性T淋巴细胞功能障碍，这可能会影响COVID-19疫苗的长期有效性。CD45的K值可能有助于在感染早期区分重症和非重症病例。也许CD45可以提高诊断敏感性。
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