Royal College of Surgeons in Ireland.
Critical Care Department - King Hamad University Hospital, Kingdom of Bahrain.
Blood Coagul Fibrinolysis. 2020 Oct;31(7):421-425. doi: 10.1097/MBC.0000000000000937.
: Septic shock is a common cause of admission in the ICUs. Despite tremendous improvement in the management modalities, mortality remains high. Early diagnosis and prompt resuscitation are required to improve prognosis. Therefore, identifying a biomarker that could reveal the sepsis at its earlier stage is of paramount importance. In this regards, platelet parameters, such as mean platelet volume, immature platelet fraction and platelet-derived microparticles have been investigated as possible sepsis biomarkers. In fact, haemostasis disturbances are one of the hallmark of septic shock where platelets play a pivotal role in orchestrating the inflammatory response of the host. Moreover, these parameters could have a prognostic value as the severity of the multiorgan dysfunction is correlated with the inflammatory reaction.
脓毒性休克是 ICU 住院的常见原因。尽管在治疗方式上有了巨大的进步，但死亡率仍然很高。早期诊断和及时复苏是改善预后所必需的。因此，寻找一种能够更早发现脓毒症的生物标志物至关重要。在这方面，血小板参数，如平均血小板体积、未成熟血小板分数和血小板衍生的微颗粒，已被研究作为可能的脓毒症生物标志物。事实上，止血紊乱是脓毒性休克的特征之一，其中血小板在调节宿主的炎症反应中起着关键作用。此外，这些参数可能具有预后价值，因为多器官功能障碍的严重程度与炎症反应相关。
