From the Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, Taiwan (P-CH); Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (P-CH); Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan (J-WC, Y-CY); Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan (M-JJ); Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan (M-JJ); and Department of Pediatrics, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan (M-JJ).
Am J Phys Med Rehabil. 2021 Aug 1;100(8):760-765. doi: 10.1097/PHM.0000000000001627.
The relationship between autoimmune rheumatic diseases, inflammatory bowel diseases, and carpal tunnel syndrome is unclear. We aimed to survey the occurrence and characteristics of carpal tunnel syndrome in autoimmune rheumatic diseases and inflammatory bowel diseases, compared with the general population.
We used the Longitudinal Health Insurance Database 2015 from Taiwan's National Health Insurance Research Database. Patients diagnosed with autoimmune rheumatic diseases/inflammatory bowel diseases were identified. The incidence rates and surgical rates of carpal tunnel syndrome among individual diseases were calculated. The hazard ratios when compared with age and sex matched, and 1:1 ratio control groups were surveyed.
A total of 2591 women and 701 men were identified. The incidence rate of carpal tunnel syndrome was highest in Crohn disease (1001 per 100,000 person-years, 95% confidence interval = 0-2747), followed by scleroderma and Sjögren syndrome. The incidence rate in the control group was 571 per 100,000 person-years (95% confidence interval = 314-829). Significantly increased adjusted hazard ratios were seen in Sjögren syndrome (1.44, 95% confidence interval = 1.09-1.90) and rheumatic arthritis (1.33, 95% confidence interval = 1.05-1.70). The overall surgical rate was 0.2% in patients with autoimmune rheumatic diseases/inflammatory bowel diseases and 0.3% in the control group, without a significant difference (P = 0.85).
Patients with Sjögren syndrome and rheumatic arthritis are susceptible to carpal tunnel syndrome. Patients with autoimmune rheumatic diseases/inflammatory bowel diseases have similar surgical rates as general population.
自身免疫性风湿病、炎症性肠病和腕管综合征之间的关系尚不清楚。我们旨在调查自身免疫性风湿病和炎症性肠病患者中腕管综合征的发生和特征，并与普通人群进行比较。
我们使用了来自台湾全民健康保险研究数据库的 2015 年纵向健康保险数据库。确定了自身免疫性风湿病/炎症性肠病患者。计算了各种疾病中腕管综合征的发生率和手术率。并比较了与年龄和性别匹配以及 1:1 比例对照组的风险比。
共确定了 2591 名女性和 701 名男性。克罗恩病的腕管综合征发生率最高（1001 人/100000 人年，95%置信区间=0-2747），其次是硬皮病和干燥综合征。对照组的发生率为 571 人/100000 人年（95%置信区间=314-829）。干燥综合征（1.44，95%置信区间=1.09-1.90）和类风湿性关节炎（1.33，95%置信区间=1.05-1.70）的校正后的风险比显著升高。自身免疫性风湿病/炎症性肠病患者的总体手术率为 0.2%，对照组为 0.3%，差异无统计学意义（P=0.85）。
干燥综合征和类风湿关节炎患者易患腕管综合征。自身免疫性风湿病/炎症性肠病患者的手术率与普通人群相似。
