Department of Pediatrics, Division of General Pediatrics.
Department of Public Health Sciences, Hollings Cancer Center & South Carolina Clinical and Translational Research Institute, Medical University of South Carolina, Charleston, SC.
J Pediatr Hematol Oncol. 2021 Oct 1;43(7):e1000-e1002. doi: 10.1097/MPH.0000000000001974.
Adequate bone marrow recovery is a discharge requirement after admission for febrile neutropenia in oncology patients, without specific threshold in consensus guidelines. In January 2016, our institution implemented count recovery criteria of absolute neutrophil count ≥100 cells/μL and absolute phagocyte count ≥300 cells/μL compared with prior criteria of absolute neutrophil count ≥500 cells/μL. Retrospective analysis comparing pre (July 2013 to December 2015, N=68) and post (January 2016 to June 2018, N=30) groups showed no difference in readmissions (P>0.9), no patient deaths, and decreased average length of stay in the post group (P<0.0001). Updated count recovery criteria seem feasible and safe.
充分的骨髓恢复是肿瘤患者因发热性中性粒细胞减少症入院后的出院要求，共识指南中没有具体的阈值。2016 年 1 月，我院实施了绝对中性粒细胞计数≥100 个/μL 和绝对吞噬细胞计数≥300 个/μL 的计数恢复标准，而之前的标准为绝对中性粒细胞计数≥500 个/μL。回顾性分析比较了前（2013 年 7 月至 2015 年 12 月，N=68）和后（2016 年 1 月至 2018 年 6 月，N=30）两组，结果显示再入院率（P>0.9）、无患者死亡以及在后组中平均住院时间缩短（P<0.0001）没有差异。更新的计数恢复标准似乎是可行和安全的。
