University of Brest, School of Medicine, Laboratoire Interactions Epithéliums-Neurones (Univ Brest, LIEN), F-29200 Brest, France.
Department of Dermatology, University Hospital of Brest, F-29200 Brest, France.
Cells. 2020 Oct 14;9(10):2291. doi: 10.3390/cells9102291.
Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with potent neurotoxins called ciguatoxins (CTXs). Ciguatera is a complex clinical syndrome in which peripheral neurological signs predominate in the acute phase of the intoxication but also persist or reoccur long afterward. Their recognition is of particular importance in establishing the diagnosis, which is clinically-based and can be a challenge for physicians unfamiliar with CFP. To date, no specific treatment exists. Physiopathologically, the primary targets of CTXs are well identified, as are the secondary events that may contribute to CFP symptomatology. This review describes the clinical features, focusing on the sensory disturbances, and then reports on the neuronal targets and effects of CTXs, as well as the neurophysiological and histological studies that have contributed to existing knowledge of CFP neuropathophysiology at the molecular, neurocellular and nerve levels.
雪卡毒素中毒（CFP）是世界范围内最常见的海鲜中毒，由食用受强效神经毒素雪卡毒素（CTXs）污染的热带和亚热带鱼类引起。雪卡毒素中毒是一种复杂的临床综合征，在中毒的急性期以周围神经体征为主，但也会持续存在或长期复发。在确定诊断时，识别这些体征尤为重要，因为对于不熟悉雪卡毒素中毒的医生来说，这可能具有挑战性。迄今为止，尚无特定的治疗方法。从病理生理学角度来看，CTXs 的主要靶标已经明确，可能导致雪卡毒素中毒症状的继发事件也已明确。本综述描述了临床特征，重点介绍了感觉障碍，然后报告了 CTXs 的神经元靶标和作用，以及神经生理学和组织学研究，这些研究有助于了解雪卡毒素中毒的神经病理生理学在分子、神经细胞和神经水平上的现有知识。
