Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Int J Mol Sci. 2020 Oct 14;21(20):7577. doi: 10.3390/ijms21207577.
Peptide-based fibrous supramolecular assemblies represent an emerging class of biomaterials that can realize various bioactivities and structures. Recently, a variety of peptide fibers with attractive functions have been designed together with the discovery of many peptide-based self-assembly units. Cross-linking of the peptide fibers is a key strategy to improve the functions of these materials. The cross-linking of peptide fibers forming three-dimensional networks in a dispersion can lead to changes in physical and chemical properties. Hydrogelation is a typical change caused by cross-linking, which makes it applicable to biomaterials such as cell scaffold materials. Cross-linking methods, which have been conventionally developed using water-soluble covalent polymers, are also useful in supramolecular peptide fibers. In the case of peptide fibers, unique cross-linking strategies can be designed by taking advantage of the functions of amino acids. This review focuses on the current progress in the design of cross-linked peptide fibers and their applications.
基于肽的纤维超分子组装体代表了一类新兴的生物材料，可实现多种生物活性和结构。最近，随着许多基于肽的自组装单元的发现，设计出了各种具有吸引力功能的肽纤维。交联是提高这些材料功能的关键策略。肽纤维在分散体中形成三维网络的交联会导致物理和化学性质的变化。凝胶化是交联引起的典型变化，使其适用于细胞支架材料等生物材料。传统上使用水溶性共价聚合物开发的交联方法在超分子肽纤维中也很有用。在肽纤维的情况下，可以利用氨基酸的功能设计独特的交联策略。本综述重点介绍了交联肽纤维的设计及其应用的最新进展。
