Department of Neurosurgery, The First People's Hospital of Jingmen, Jingmen, Hubei, PR China.
Department of Neurology, The First People's Hospital of Jingmen, Jingmen, Hubei, PR China.
J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105208. doi: 10.1016/j.jstrokecerebrovasdis.2020.105208. Epub 2020 Aug 4.
Aneurysmal subarachnoid hemorrhage (aSAH) is both a hypercoagulable and inflammation state in which many biomarkers have been studied. Activated platelets have been identified to be of clinical importance in thrombosis and neuroinflammation after aSAH. The aim of this study was to investigate the relationship between mean platelet volume (MPV) to platelet count (PC) ratio, a surrogate parameter for activated platelets, and the functional outcome in aSAH patients.
A retrospective analysis was performed of patients with aSAH admitted to the stroke center of our institution between November 2018 and November 2019. The mean MPV/PC ratio during the first three days after aSAH onset was calculated. Poor outcome was defined as a modified Rankin Scale (mRS) score of 3-6 at 3 months. Receive operating characteristic (ROC) curve analysis was performed to determine the optimal value of MPV/PC ratio for the prediction of poor outcome in patients with aSAH.
A total of 100 patients were included, 13 (13.0%) died and 35 (35.0%) had a poor outcome. Mean MPV/PC ratio (P < 0.001) when measured over the study period, was significantly higher among patients with poor outcome. In multivariable analysis, increased mean MPV/PC ratio was associated with poor functional outcome at 3 months (odds ratio (OR) = 1.94; 95% confidence interval (CI): 1.19-3.17; P = 0.008). The optimal cutoff of MPV/PC ratio for predicting poor outcome at 3 months was 6.77 (sensitivity 74.3%, specificity 61.5%).
An increased MPV/PC ratio is associated with poor functional outcome in aSAH patients. MPV/PC ratio may be a useful predictor of outcome after aSAH.
蛛网膜下腔出血（aSAH）既是一种高凝状态，也是一种炎症状态，许多生物标志物在其中得到了研究。活化血小板已被确定在 aSAH 后血栓形成和神经炎症中具有临床重要性。本研究旨在探讨平均血小板体积（MPV）与血小板计数（PC）比值（血小板活化的替代参数）与 aSAH 患者功能结局之间的关系。
对 2018 年 11 月至 2019 年 11 月期间入住我院卒中中心的 aSAH 患者进行回顾性分析。计算 aSAH 发病后前 3 天的平均 MPV/PC 比值。预后不良定义为 3 个月时改良 Rankin 量表（mRS）评分 3-6 分。进行接收者操作特征（ROC）曲线分析，以确定 MPV/PC 比值对预测 aSAH 患者不良预后的最佳值。
共纳入 100 例患者，13 例（13.0%）死亡，35 例（35.0%）预后不良。在研究期间测量的平均 MPV/PC 比值（P < 0.001）在预后不良的患者中显著更高。多变量分析显示，研究期间平均 MPV/PC 比值升高与 3 个月时功能预后不良相关（比值比（OR）= 1.94；95%置信区间（CI）：1.19-3.17；P = 0.008）。MPV/PC 比值预测 3 个月时预后不良的最佳截断值为 6.77（敏感性 74.3%，特异性 61.5%）。
aSAH 患者中 MPV/PC 比值升高与功能预后不良相关。MPV/PC 比值可能是 aSAH 后预后的有用预测指标。
