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[磁共振成像中诊断心脏淀粉样变性:鉴别因素]

[Diagnosing cardiac amyloidosis in magnetic resonance imaging: The discriminating factors].

作者信息

Goïorani F, Dagrenat C, Brocchi J, Couppie P, Leddet P

机构信息

Service de cardiologie, unité thérapeutique d'insuffisance cardiaque, 64, avenue du Pr-Leriche, 67500 Haguenau, France.

Service de cardiologie, unité thérapeutique d'insuffisance cardiaque, 64, avenue du Pr-Leriche, 67500 Haguenau, France.

出版信息

Ann Cardiol Angeiol (Paris). 2020 Nov;69(5):262-267. doi: 10.1016/j.ancard.2020.09.023. Epub 2020 Oct 14.

Abstract

Infiltrative cardiomyopathies refers to deposits of substances in the myocardial tissue resulting in a structural abnormality and/or alteration of cardiac function. Cardiac amyloidosis is an extracellular infiltration of amyloid fibril. Cardiac magnetic resonance imaging (MRI) is essential (in the) for its diagnosis. MRI sequences (morphological, viability and parametric mapping) allow a structural and dynamic analysis of the cardiac function as well as a characterization of the myocardial tissue: edema, fatty infiltration, fibrosis. In cardiac amyloidosis, the morphological sequences classically highlight ventricular hypertrophy and thickening of the heart valves. Ventricular functions are assessed by the cine sequences (The cine sequences make it possible to evaluate the ventricular functions.) The viability sequences show (a more diffuse distribution of hypersignals) an abnormal pattern of late gadolinium enhancement in both circumferential and sub-endocardial distribution. The relaxometry sequences or parametric T1 and/or T2 mapping allow the spatial visualization of quantitative changes of the myocardium. The presence of macroscopic myocardial edema or fibrosis causes a prolongation of the native T1 and an increase of the extracellular volume.

摘要

浸润性心肌病是指物质沉积于心肌组织,导致结构异常和/或心脏功能改变。心脏淀粉样变性是淀粉样纤维的细胞外浸润。心脏磁共振成像(MRI)对其诊断至关重要。MRI序列(形态学、存活心肌及参数成像)可对心脏功能进行结构和动态分析,并对心肌组织进行特征描述:水肿、脂肪浸润、纤维化。在心脏淀粉样变性中,形态学序列通常显示心室肥厚和心脏瓣膜增厚。通过电影序列评估心室功能(电影序列能够评估心室功能)。存活心肌序列显示(高信号分布更弥散)钆延迟增强呈异常模式,呈圆周和心内膜下分布。弛豫测量序列或参数T1和/或T2成像可对心肌的定量变化进行空间可视化。宏观心肌水肿或纤维化的存在会导致固有T1延长和细胞外容积增加。

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