TERT 基因座多态性（rs36115365）在手术切除的非小细胞肺癌中的预后意义。
The Prognostic Significance of TERT Locus Polymorphism (rs36115365) in Surgically Resected Non-Small Cell Lung Cancer.
机构信息
Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.
Department of Anatomy, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea.
出版信息
Ann Clin Lab Sci. 2020 Sep;50(5):645-649.
OBJECTIVE
Telomere length is an important factor for the development of non-small cell lung cancer (NSCLC), and current articles focused on telomere associated genes. We studied the clinicopathological and prognostic implications of rs36115365 polymorphism of the TERT-CLPTM1L locus in NSCLC. The association between rs36115365 and telomere length was investigated in 176 NSCLCs.
METHODS
DNA was extracted from NSCLC tissues and polymorphism and telomere length were analyzed.
RESULTS
The rs36115365 polymorphism showed the following frequencies according to the genotype: G/G in 81.8% of the patients, G/C in 14.2%, and C/C in 4.0%. Average telomere length in the tumor tissues were 3.06-fold longer than telomeres in paired non-tumor tissues (SD=1.87), and telomere length was not significantly different according to rs36115365 (=0.134). The rs36115365 polymorphism did not have any relationships with clinicopathological characteristics. A poor overall survival result was found in NSCLC with C allele carriers than that with G/G allele (=0.034). However, disease free survival rate was not different statistically (=0.938).
CONCLUSIONS
These findings suggest that rs36115365 may contribute to the progression of NSCLC.
目的
端粒长度是非小细胞肺癌（NSCLC）发展的一个重要因素，目前的研究集中在端粒相关基因上。我们研究了 TERT-CLPTM1L 基因座 rs36115365 多态性与 NSCLC 的临床病理和预后的关系。在 176 例 NSCLC 中，研究了 rs36115365 与端粒长度的相关性。
方法
从 NSCLC 组织中提取 DNA，分析多态性和端粒长度。
结果
rs36115365 多态性的基因型频率分别为：G/G 占 81.8%，G/C 占 14.2%，C/C 占 4.0%。肿瘤组织中的平均端粒长度比配对的非肿瘤组织长 3.06 倍（标准差=1.87），但 rs36115365 与端粒长度无显著差异（=0.134）。rs36115365 多态性与临床病理特征无任何关系。与 G/G 等位基因携带者相比，C 等位基因携带者的 NSCLC 总生存结果较差（=0.034）。然而，无病生存率无统计学差异（=0.938）。
结论
这些发现表明，rs36115365 可能与 NSCLC 的进展有关。
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