[半胱胺与缺氧对大肠杆菌突变体的保护作用]
[Protective effects of cysteamine and anoxia in Escherichia coli mutants].
作者信息
Korystov Iu N, Veksler F B
出版信息
Radiobiologiia. 1987 Jul-Aug;27(4):516-21.
The values of the oxygen effect (m) and maximum radioprotective effect of cysteamine (DMF*) have been determined for the following Escherichia coli strains: AB1157 (the wild type), AB1886 (uvrA), AB2463 (recA), and p3478 (polA). Three mechanisms are shown to be responsible for the protective effect of cysteamine, they are: (1) anoxia, (2) diminution of the indirect effect, (3) an increased efficiency of enzyme repair. Anoxia is the main contributor to the protective effect in all the strains under study while mechanism (3) is only effective in the wild type strain.
已测定了以下大肠杆菌菌株的氧效应值（m）和半胱胺的最大辐射防护效应（DMF*）：AB1157（野生型）、AB1886（uvrA）、AB2463（recA）和p3478（polA）。结果表明，半胱胺的防护效应由三种机制引起，即：（1）缺氧，（2）间接效应减弱，（3）酶修复效率提高。在所有研究的菌株中，缺氧是防护效应的主要贡献因素，而机制（3）仅在野生型菌株中有效。
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