Zhao Sha-Sha, Zhu Xiao-Jing, Wu Run-Hui
Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education;Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University , National Center for children's Health, Beijing 100045, China.
Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education;Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University , National Center for children's Health, Beijing 100045, China,E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Oct;28(5):1674-1678. doi: 10.19746/j.cnki.issn.1009-2137.2020.05.040.
To explore the correlation between the of regulatory T cells, Th17 cells and the prognosis of children with aplastic anemia.
The clinical data 13 children with aplastic anemia (AA) treated by antithymocyte globulin (ATG) combined with Cyclosporine in Beijing Children's Hospital, Capital Medical University from January 2017 to January 2018 were analyized retrospectively. The changes of T cell and Th17 cell expression level in peripheral blood of AA children before and after IST for 6 and 12 month were compared and analyzed. The SPSS 19.0 statistical package was used for data analysis.
Compared with the pre-IST, the expression level of Treg cells decreased at 6 months of IST, the difference was statistically significant (P＜0.05); however the expression level of Th17 cells did not show significant difference as compared with that pre-IST. The expression level of Treg and Th17 cells at 12 months of IST was lower than that pre-IST (P＜0.01), compared with the level pre-IST, the ratio of Treg cells/Th17 cell at 6 months and 12 months of IST did not show a singificand difference.
Treg cells and Th17 cells in peripheral blood of AA children decrease after IST, which suggests that the change of regulatory T cells and Th17 cells correlate with the clinical outcome of children with aplastic anemia.
探讨调节性T细胞、Th17细胞与再生障碍性贫血患儿预后的相关性。
回顾性分析2017年1月至2018年1月在首都医科大学附属北京儿童医院接受抗胸腺细胞球蛋白（ATG）联合环孢素治疗的13例再生障碍性贫血（AA）患儿的临床资料。比较并分析AA患儿免疫抑制治疗（IST）前及IST后6个月和12个月外周血中T细胞及Th17细胞表达水平的变化。采用SPSS 19.0统计软件进行数据分析。
与IST前比较，IST 6个月时调节性T细胞表达水平降低，差异有统计学意义（P＜0.05）；而Th17细胞表达水平与IST前比较差异无统计学意义。IST 12个月时调节性T细胞及Th17细胞表达水平均低于IST前（P＜0.01），与IST前水平比较，IST 6个月及12个月时调节性T细胞/Th17细胞比值差异无统计学意义。
AA患儿IST后外周血调节性T细胞和Th17细胞减少，提示调节性T细胞和Th17细胞的变化与再生障碍性贫血患儿的临床转归相关。
