Wallwork J C
Prog Food Nutr Sci. 1987;11(2):203-47.
The effect of zinc nutriture and metabolism on brain function has been reviewed. Zinc nutriture and its effect on the concentration and metabolism of essential elements (e.g. zinc, copper, manganese, magnesium, sodium, potassium and calcium) and on the concentration and metabolism of toxic elements (e.g. aluminum and lead) are discussed in relationship to brain function. In addition, possible interrelationships between zinc nutriture and metabolism and its effect on a number of diseases including acrodermatitis enteropathica, Pick's disease, Alzheimer's disease, schizophrenia, fifth day fits, and epilepsy are discussed. Descriptions and comparisons of methods to measure brain zinc are presented. Behavioral changes and the altered brain morphology which have been associated with zinc deficiency are reviewed. Some possible mechanisms for the association of anorexia with zinc deficiency are outlined. Perinatal brain damage produced by early zinc deficiency followed by rehabilitation with adequate zinc appears to be long term, maybe permanent. Interrelationships between zinc nutriture and aspects of neurochemistry are outlined. Some of the neurochemistries discussed include nucleic acid and protein synthesis, cytoskeletal proteins, neurotransmitters (e.g. catecholamines, indoleamines, glutamate, gamma-aminobutyric acid, and neuropeptides), neurotransmitter receptors, 7S nerve growth factor and zinc-binding proteins. Recent evidence linking zinc and neurotransmission is discussed.
锌营养与代谢对脑功能的影响已得到综述。文中讨论了锌营养及其对必需元素（如锌、铜、锰、镁、钠、钾和钙）的浓度与代谢以及对有毒元素（如铝和铅）的浓度与代谢的影响，并将其与脑功能联系起来。此外，还讨论了锌营养与代谢之间可能的相互关系及其对多种疾病的影响，这些疾病包括肠病性肢端皮炎、皮克病、阿尔茨海默病、精神分裂症、五日惊厥和癫痫。文中介绍并比较了测量脑锌的方法。综述了与锌缺乏相关的行为变化和脑形态改变。概述了厌食与锌缺乏相关的一些可能机制。早期锌缺乏继而用充足的锌进行康复治疗所导致的围产期脑损伤似乎具有长期影响，甚至可能是永久性的。文中概述了锌营养与神经化学各方面之间的相互关系。所讨论的一些神经化学内容包括核酸和蛋白质合成、细胞骨架蛋白、神经递质（如儿茶酚胺、吲哚胺、谷氨酸、γ-氨基丁酸和神经肽）、神经递质受体、7S神经生长因子和锌结合蛋白。讨论了锌与神经传递相关的最新证据。
