间斑寇蛛（蜘蛛纲：球蛛科）咬伤中毒：F(ab')抗蛇毒血清治疗后症状迅速缓解

Latrodectus geometricus (Aranea: Theridiidae) envenoming: Rapid resolution of symptoms following F(ab') antivenom therapy.

作者信息

Keyler D E, Ahmad M, Rodriguez A, De Silva P M K

机构信息

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.

Metropolitan Methodist Hospital, San Antonio, TX, USA.

出版信息

Toxicon. 2020 Dec;188:76-79. doi: 10.1016/j.toxicon.2020.10.009. Epub 2020 Oct 14.

DOI:10.1016/j.toxicon.2020.10.009

PMID:33068558

Abstract

The Brown Widow spider (Latrodectus geometricus) is an invasive species whose geographic range has been expanding worldwide. It is a relative species of the Black Widow and Red-backed spiders of the genus Latrodectus. Despite its broad geographic distribution cases of Brown Widow envenomation have rarely been documented. The venom of L. geometricus is similar to the venom of L. mactans with the primary venom component being alpha-latrotoxin, and consequent envenoming by L. geometricus to humans has resulted in symptoms similar to those reported for other Latrodectus spp. Specific FDA approved Latrodectus antivenom (IgG) available in North America has been effectively used in treating venom-induced symptoms following L. mactans envenoming. The patient reported here involved a confirmed L. geometricus envenoming who was efficaciously treated with an alternately available F(ab') antivenom from Mexico.

摘要

褐寡妇蜘蛛（间斑寇蛛）是一种入侵物种，其地理分布范围在全球不断扩大。它是寇蛛属黑寡妇蜘蛛和红背蜘蛛的近亲物种。尽管其地理分布广泛，但褐寡妇蜘蛛蜇伤的病例却鲜有记录。间斑寇蛛的毒液与澳洲红背蜘蛛的毒液相似，主要毒液成分是α - 拉毒素，因此间斑寇蛛对人类的蜇伤所导致的症状与其他寇蛛属物种报告的症状相似。北美有美国食品药品监督管理局（FDA）批准的特定寇蛛属抗蛇毒血清（IgG），已有效用于治疗澳洲红背蜘蛛蜇伤后的毒液引发症状。此处报告的患者是一例确诊的间斑寇蛛蜇伤病例，使用从墨西哥获取的一种替代可用的F(ab')抗蛇毒血清对其进行了有效治疗。