Department of Radiology, University of Washington, Seattle, WA, USA.
Department of Electrical and Computer Engineering, University of Washington, Seattle, WA, USA.
Magn Reson Imaging. 2021 Jan;75:45-50. doi: 10.1016/j.mri.2020.10.004. Epub 2020 Oct 15.
To characterize the intracranial vascular features extracted from time of flight (TOF) images and their changes from baseline to follow-up in patients undergoing carotid revascularization, using arterial spin labeling (ASL) cerebral blood flow (CBF) measurement as a reference.
In this retrospective study, brain TOF and ASL images of 99 subjects, acquired before, within 48 h, and/or 6 months after, carotid revascularization surgery were analyzed. TOF images were analyzed using a custom software (iCafe) to quantify intracranial vascular features, including total vessel length, total vessel volume, and number of branches. Mean whole-brain CBF was calculated from ASL images. ASL scans showing low ASL signal in the entire flow territory of an internal carotid artery (ICA), which may be caused by labeling failure, were excluded. Changes and correlations between time points were analyzed separately for TOF intracranial vascular features and ASL CBF.
Similar to ASL CBF, TOF vascular features (i.e. total vessel length, total vessel volume and number of branches) increased dramatically from baseline to post-surgery, then returned to a level slightly higher than the baseline in long-term follow-up (All P < 0.05). Correlation between time points was observed for all three TOF vascular features but not for ASL CBF.
Intracranial vascular features, including total vessel length, total vessel volume and number of branches, extracted from TOF images are useful in detecting brain blood flow changes induced by carotid revascularization surgery.
利用动脉自旋标记（ASL）脑血流（CBF）测量作为参考，描述从 TOF 图像中提取的颅内血管特征及其从基线到随访的变化，这些患者正在接受颈动脉血运重建。
在这项回顾性研究中，分析了 99 例患者的脑 TOF 和 ASL 图像，这些图像分别在颈动脉血运重建手术前、术后 48 小时内和/或 6 个月内采集。使用定制软件（iCafe）分析 TOF 图像，以量化颅内血管特征，包括总血管长度、总血管体积和分支数量。从 ASL 图像计算平均全脑 CBF。排除 ASL 信号在颈内动脉（ICA）整个血流区域均较低的 ASL 扫描，这可能是由于标记失败引起的。分别分析了 TOF 颅内血管特征和 ASL CBF 的时间点之间的变化和相关性。
与 ASL CBF 相似，TOF 血管特征（即总血管长度、总血管体积和分支数量）从基线到手术后急剧增加，然后在长期随访中恢复到略高于基线的水平（均 P<0.05）。观察到所有三个 TOF 血管特征的时间点之间存在相关性，但 ASL CBF 则没有。
从 TOF 图像中提取的颅内血管特征，包括总血管长度、总血管体积和分支数量，可用于检测颈动脉血运重建手术引起的脑血流变化。
