Université de Nantes, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.
Université de Nantes, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.
J Neuroimmunol. 2020 Dec 15;349:577422. doi: 10.1016/j.jneuroim.2020.577422. Epub 2020 Oct 7.
Plexitis in the proximal margin of intestinal resections are associated with post-operative recurrence of Crohn's disease. To understand their formation, in vitro analyzes were performed. T cells adhered preferentially to neuron and glial cells in mixed primary cultures of enteric nervous system and T cell activation increased their adhesion capacity. Higher number of T lymphocytes in close proximity to enteric glial cells was also observed in the myenteric ganglia of Crohn's patients as compared to control. These data show that close proximity between lymphocytes and enteric neural cells exists and may contribute to the formation of plexitis.
肠切除术后近端边缘的神经丛炎与克罗恩病的术后复发有关。为了了解其形成机制，进行了体外分析。T 细胞在肠神经系统的混合原代培养物中的神经元和神经胶质细胞上优先黏附，T 细胞的激活增加了它们的黏附能力。与对照组相比，克罗恩病患者的肌间神经节中也观察到更多的 T 淋巴细胞靠近肠神经胶质细胞。这些数据表明，淋巴细胞和肠神经细胞之间存在密切接触，可能有助于神经丛炎的形成。
