[E2F1在常见肿瘤中的研究进展]
[Advancement of E2F1 in Common Tumors].
作者信息
Shen Cheng, Li Jue, Chang Shuai, Che Guowei
机构信息
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2020 Oct 20;23(10):921-926. doi: 10.3779/j.issn.1009-3419.2020.101.32.
Abstract
The cell cycle-related transcription factor E2F1 is a member of the cell cycle-related transcription factor E2F family, mainly involved in various cell processes including cell cycle progression, DNA repair, DNA replication, cell differentiation, proliferation, and apoptosis. E2F1 is highly expressed in a variety of tumor tissues and cells, and it plays a role as a cancer-promoting gene. The up-regulation of E2F1 expression is closely related to the occurrence, development, metastasis and prognosis of tumors. Therefore, E2F1 is expected to become a new target for cancer treatment. This article reviews the latest research progress of E2F1 in current common tumors. .
摘要
细胞周期相关转录因子E2F1是细胞周期相关转录因子E2F家族的成员，主要参与包括细胞周期进程、DNA修复、DNA复制、细胞分化、增殖和凋亡在内的各种细胞过程。E2F1在多种肿瘤组织和细胞中高表达，发挥促癌基因的作用。E2F1表达上调与肿瘤的发生、发展、转移及预后密切相关。因此，E2F1有望成为癌症治疗的新靶点。本文综述了E2F1在当前常见肿瘤中的最新研究进展。
相似文献
1
[Advancement of E2F1 in Common Tumors].[E2F1在常见肿瘤中的研究进展]
Zhongguo Fei Ai Za Zhi. 2020 Oct 20;23(10):921-926. doi: 10.3779/j.issn.1009-3419.2020.101.32.
2
E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells.E2F1和E2F2对DNA损伤的诱导反应可维持神经元细胞的基因组稳定性。
Cell Cycle. 2015;14(8):1300-14. doi: 10.4161/15384101.2014.985031.
3
The role of E2F2 in cancer progression and its value as a therapeutic target.E2F2 在癌症进展中的作用及其作为治疗靶点的价值。
Front Immunol. 2024 May 14;15:1397303. doi: 10.3389/fimmu.2024.1397303. eCollection 2024.
4
Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence.E2F1 和 E2F2 缺陷型巨噬细胞中的加速 DNA 复制导致 DNA 损伤反应和 p21(CIP1)依赖性衰老的诱导。
Oncogene. 2010 Oct 14;29(41):5579-90. doi: 10.1038/onc.2010.296. Epub 2010 Aug 2.
5
Expression and prognostic value of E2F activators in NSCLC and subtypes: a research based on bioinformatics analysis.E2F激活剂在非小细胞肺癌及其亚型中的表达与预后价值：一项基于生物信息学分析的研究
Tumour Biol. 2016 Nov;37(11):14979-14987. doi: 10.1007/s13277-016-5389-z. Epub 2016 Sep 21.
6
E2F1 in gliomas: a paradigm of oncogene addiction.神经胶质瘤中的E2F1：癌基因成瘾范例
Cancer Lett. 2008 May 18;263(2):157-63. doi: 10.1016/j.canlet.2008.02.001. Epub 2008 Mar 10.
7
E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.E2F1和E2F2可预防复制应激及随后的p53依赖性器官退化。
Cell Death Differ. 2015 Oct;22(10):1577-89. doi: 10.1038/cdd.2015.4. Epub 2015 Feb 6.
8
Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury.转录因子E2F1-2的缺失可限制脊髓挫伤性损伤后的神经炎症及相关神经功能缺损。
Cell Cycle. 2015;14(23):3698-712. doi: 10.1080/15384101.2015.1104436.
9
Transcription factor compensation during mammary gland development in E2F knockout mice.E2F 敲除小鼠乳腺发育过程中的转录因子补偿。
PLoS One. 2018 Apr 4;13(4):e0194937. doi: 10.1371/journal.pone.0194937. eCollection 2018.
10
The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases.E2F家族成员与结直肠癌肿瘤生长的关系：100例病例的比较免疫组化研究
Appl Immunohistochem Mol Morphol. 2014 Jul;22(6):471-7. doi: 10.1097/PAI.0b013e3182598198.
引用本文的文献
1
Mathematical Models Including microRNA Levels of Mesenteric Adipose Tissue May Predict Postoperative Relapse in Crohn's Disease Patients.包括肠系膜脂肪组织微小RNA水平的数学模型可能预测克罗恩病患者术后复发情况。
Gastro Hep Adv. 2023 Sep 14;3(1):17-30. doi: 10.1016/j.gastha.2023.08.020. eCollection 2024.
2
Antitumorigenic potential of Lactobacillus-derived extracellular vesicles: p53 succinylation and glycolytic reprogramming in intestinal epithelial cells via SIRT5 modulation.乳酸菌来源的细胞外囊泡的抗肿瘤潜力：通过 SIRT5 调节在肠道上皮细胞中 p53 的琥珀酰化和糖酵解重编程。
Cell Biol Toxicol. 2024 Aug 7;40(1):66. doi: 10.1007/s10565-024-09897-y.
3
Biological roles of SLC16A1-AS1 lncRNA and its clinical impacts in tumors.SLC16A1-AS1长链非编码RNA的生物学作用及其在肿瘤中的临床影响
Cancer Cell Int. 2024 Mar 30;24(1):122. doi: 10.1186/s12935-024-03285-6.
4
Long non-coding RNA CDKN2B-AS1 promotes hepatocellular carcinoma progression E2F transcription factor 1/G protein subunit alpha Z axis.长链非编码RNA CDKN2B-AS1通过E2F转录因子1/G蛋白亚基αZ轴促进肝细胞癌进展。
World J Gastrointest Oncol. 2023 Nov 15;15(11):1974-1987. doi: 10.4251/wjgo.v15.i11.1974.
5
Identifying the Interaction Between Tuberculosis and SARS-CoV-2 Infections via Bioinformatics Analysis and Machine Learning.通过生物信息学分析和机器学习识别结核病和 SARS-CoV-2 感染之间的相互作用。
Biochem Genet. 2024 Aug;62(4):2606-2630. doi: 10.1007/s10528-023-10563-x. Epub 2023 Nov 22.
6
A network pharmacology and bioinformatics exploration of the possible molecular mechanisms of Fuzheng Xiaoliu Granule for the treatment of hepatocellular carcinoma.扶正消瘤颗粒治疗肝细胞癌可能分子机制的网络药理学与生物信息学探索
J Clin Transl Res. 2023 May 12;9(3):182-194. eCollection 2023 Jun 29.
7
CDC25A inhibition suppresses cell proliferation and induces G/S‑phase cell cycle arrest in nasopharyngeal carcinoma.CDC25A 抑制可抑制鼻咽癌细胞增殖并诱导 G/S 期细胞周期停滞。
Mol Med Rep. 2023 May;27(5). doi: 10.3892/mmr.2023.12996. Epub 2023 Apr 13.
本文引用的文献
1
[miR-449a/b negatively regulates E2F1 to suppress proliferation of gastric cancer cells].[微小RNA-449a/b负向调控E2F1以抑制胃癌细胞增殖]
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jan 30;40(1):13-19. doi: 10.12122/j.issn.1673-4254.2020.01.03.
2
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer.E2F1 和 EIF4A3 介导的 circRNA circSEPT9 促进三阴性乳腺癌的发生发展。
Mol Cancer. 2020 Apr 7;19(1):73. doi: 10.1186/s12943-020-01183-9.
3
Network-based metabolic characterization of renal cell carcinoma.基于网络的肾细胞癌代谢特征分析。
Sci Rep. 2020 Apr 6;10(1):5955. doi: 10.1038/s41598-020-62853-8.
4
New relationship of E2F1 and BNIP3 with caveolin-1 in lung cancer-associated fibroblasts.E2F1 和 BNIP3 与肺癌相关成纤维细胞中窖蛋白-1的新关系。
Thorac Cancer. 2020 Jun;11(6):1369-1371. doi: 10.1111/1759-7714.13408. Epub 2020 Mar 25.
5
MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression.miRNA-34a 的表达通过下调 E2F1 和 E2F3 的表达影响体外乳腺癌侵袭和患者生存。
Oncol Rep. 2020 Jun;43(6):2062-2072. doi: 10.3892/or.2020.7549. Epub 2020 Mar 18.
6
MicroRNA-361-3p promotes human breast cancer cell viability by inhibiting the E2F1/P73 signalling pathway.微小 RNA-361-3p 通过抑制 E2F1/P73 信号通路促进人乳腺癌细胞活力。
Biomed Pharmacother. 2020 May;125:109994. doi: 10.1016/j.biopha.2020.109994. Epub 2020 Feb 25.
7
Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells.沉默 E2F 转录因子 1 后 miR-34c 的上调抑制了胃癌细胞对紫杉醇联合顺铂的耐药性。
World J Gastroenterol. 2020 Feb 7;26(5):499-513. doi: 10.3748/wjg.v26.i5.499.
8
Expression and prognostic role of E2F transcription factors in high-grade glioma.E2F 转录因子在高级别胶质瘤中的表达及预后作用。
CNS Neurosci Ther. 2020 Jul;26(7):741-753. doi: 10.1111/cns.13295. Epub 2020 Feb 16.
9
LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration.LINC00461/miR-4478/E2F1 反馈环促进非小细胞肺癌细胞的增殖和迁移。
Biosci Rep. 2020 Feb 28;40(2). doi: 10.1042/BSR20191345.
10
LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer.长链非编码RNA RP11-19E11是基底样乳腺癌增殖和存活所必需的E2F1靶点。
NPJ Breast Cancer. 2020 Jan 6;6:1. doi: 10.1038/s41523-019-0144-4. eCollection 2020.
Zotero 插件