[E2F1在常见肿瘤中的研究进展]
[Advancement of E2F1 in Common Tumors].
作者信息
Shen Cheng, Li Jue, Chang Shuai, Che Guowei
机构信息
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2020 Oct 20;23(10):921-926. doi: 10.3779/j.issn.1009-3419.2020.101.32.
Abstract
The cell cycle-related transcription factor E2F1 is a member of the cell cycle-related transcription factor E2F family, mainly involved in various cell processes including cell cycle progression, DNA repair, DNA replication, cell differentiation, proliferation, and apoptosis. E2F1 is highly expressed in a variety of tumor tissues and cells, and it plays a role as a cancer-promoting gene. The up-regulation of E2F1 expression is closely related to the occurrence, development, metastasis and prognosis of tumors. Therefore, E2F1 is expected to become a new target for cancer treatment. This article reviews the latest research progress of E2F1 in current common tumors. .
摘要
细胞周期相关转录因子E2F1是细胞周期相关转录因子E2F家族的成员，主要参与包括细胞周期进程、DNA修复、DNA复制、细胞分化、增殖和凋亡在内的各种细胞过程。E2F1在多种肿瘤组织和细胞中高表达，发挥促癌基因的作用。E2F1表达上调与肿瘤的发生、发展、转移及预后密切相关。因此，E2F1有望成为癌症治疗的新靶点。本文综述了E2F1在当前常见肿瘤中的最新研究进展。
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