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[E2F1在常见肿瘤中的研究进展]

[Advancement of E2F1 in Common Tumors].

作者信息

Shen Cheng, Li Jue, Chang Shuai, Che Guowei

机构信息

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2020 Oct 20;23(10):921-926. doi: 10.3779/j.issn.1009-3419.2020.101.32.

DOI:10.3779/j.issn.1009-3419.2020.101.32
PMID:33070516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7583875/
Abstract

The cell cycle-related transcription factor E2F1 is a member of the cell cycle-related transcription factor E2F family, mainly involved in various cell processes including cell cycle progression, DNA repair, DNA replication, cell differentiation, proliferation, and apoptosis. E2F1 is highly expressed in a variety of tumor tissues and cells, and it plays a role as a cancer-promoting gene. The up-regulation of E2F1 expression is closely related to the occurrence, development, metastasis and prognosis of tumors. Therefore, E2F1 is expected to become a new target for cancer treatment. This article reviews the latest research progress of E2F1 in current common tumors.
.

摘要

细胞周期相关转录因子E2F1是细胞周期相关转录因子E2F家族的成员，主要参与包括细胞周期进程、DNA修复、DNA复制、细胞分化、增殖和凋亡在内的各种细胞过程。E2F1在多种肿瘤组织和细胞中高表达，发挥促癌基因的作用。E2F1表达上调与肿瘤的发生、发展、转移及预后密切相关。因此，E2F1有望成为癌症治疗的新靶点。本文综述了E2F1在当前常见肿瘤中的最新研究进展。

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本文引用的文献

1
[miR-449a/b negatively regulates E2F1 to suppress proliferation of gastric cancer cells].[微小RNA-449a/b负向调控E2F1以抑制胃癌细胞增殖]
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jan 30;40(1):13-19. doi: 10.12122/j.issn.1673-4254.2020.01.03.
2
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer.E2F1 和 EIF4A3 介导的 circRNA circSEPT9 促进三阴性乳腺癌的发生发展。
Mol Cancer. 2020 Apr 7;19(1):73. doi: 10.1186/s12943-020-01183-9.
3
Network-based metabolic characterization of renal cell carcinoma.基于网络的肾细胞癌代谢特征分析。
Sci Rep. 2020 Apr 6;10(1):5955. doi: 10.1038/s41598-020-62853-8.
4
New relationship of E2F1 and BNIP3 with caveolin-1 in lung cancer-associated fibroblasts.E2F1 和 BNIP3 与肺癌相关成纤维细胞中窖蛋白-1的新关系。
Thorac Cancer. 2020 Jun;11(6):1369-1371. doi: 10.1111/1759-7714.13408. Epub 2020 Mar 25.
5
MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression.miRNA-34a 的表达通过下调 E2F1 和 E2F3 的表达影响体外乳腺癌侵袭和患者生存。
Oncol Rep. 2020 Jun;43(6):2062-2072. doi: 10.3892/or.2020.7549. Epub 2020 Mar 18.
6
MicroRNA-361-3p promotes human breast cancer cell viability by inhibiting the E2F1/P73 signalling pathway.微小 RNA-361-3p 通过抑制 E2F1/P73 信号通路促进人乳腺癌细胞活力。
Biomed Pharmacother. 2020 May;125:109994. doi: 10.1016/j.biopha.2020.109994. Epub 2020 Feb 25.
7
Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells.沉默 E2F 转录因子 1 后 miR-34c 的上调抑制了胃癌细胞对紫杉醇联合顺铂的耐药性。
World J Gastroenterol. 2020 Feb 7;26(5):499-513. doi: 10.3748/wjg.v26.i5.499.
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Expression and prognostic role of E2F transcription factors in high-grade glioma.E2F 转录因子在高级别胶质瘤中的表达及预后作用。
CNS Neurosci Ther. 2020 Jul;26(7):741-753. doi: 10.1111/cns.13295. Epub 2020 Feb 16.
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LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration.LINC00461/miR-4478/E2F1 反馈环促进非小细胞肺癌细胞的增殖和迁移。
Biosci Rep. 2020 Feb 28;40(2). doi: 10.1042/BSR20191345.
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NPJ Breast Cancer. 2020 Jan 6;6:1. doi: 10.1038/s41523-019-0144-4. eCollection 2020.