Yamada Shintaro, Isozaki Makoto, Yamauchi Takahiro, Arishima Hidetaka, Kodera Toshiaki, Kikuta Ken-Ichiro
Department of Neurosurgery, School of Medical Sciences, University of Fukui.
No Shinkei Geka. 2020 Oct;48(10):921-926. doi: 10.11477/mf.1436204297.
We report a case of glioblastoma due to putaminal hemorrhage. Notably, the glioblastoma was located at some distance from the hematoma. A 42-year-old right-handed man presented with a sudden-onset headache, motor aphasia, and right hemiplegia. CT showed left putaminal hemorrhage and a mass lesion with a slightly high density in the midbrain away from the hematoma. Conservative treatment was initiated for the patient. Initially, we suspected a benign tumor-like cavernous malformation based on the CT findings. However, MRI showed ring enhancement of the mass lesion on contrast-enhanced MRI and hyperintensity on arterial spin labeling(ASL). A part of the wall of the putaminal hemorrhage also exhibited hyperintensity on ASL. Since we suspected a malignant brainstem tumor and a secondary intracerebral hemorrhage caused by this tumor, we performed a stereotactic brain biopsy. Histological examination revealed that the tumor was a wild-type glioblastoma. In the acute phase, the intracerebral hemorrhage presented as a hyperintensity on T1-weighted imaging. Therefore, it was difficult to distinguish hemorrhagic glioblastoma from an intracerebral hemorrhage. Even if an intracerebral hemorrhage is observed at common sites, it is important to consider the possibility of a malignant brain tumor and complete a prompt examination. In addition, ASL imaging may be useful in detecting hemorrhagic malignant brain tumors.
我们报告一例因壳核出血导致的胶质母细胞瘤病例。值得注意的是,胶质母细胞瘤位于距血肿一定距离处。一名42岁右利手男性突发头痛、运动性失语和右侧偏瘫。CT显示左侧壳核出血以及在远离血肿的中脑有一个密度略高的肿块病变。对该患者开始进行保守治疗。最初,基于CT表现我们怀疑是良性肿瘤样海绵状畸形。然而,MRI显示对比增强MRI上肿块病变呈环形强化,动脉自旋标记(ASL)上呈高信号。壳核出血壁的一部分在ASL上也表现为高信号。由于我们怀疑是恶性脑干肿瘤以及由此肿瘤导致的继发性脑出血,我们进行了立体定向脑活检。组织学检查显示肿瘤为野生型胶质母细胞瘤。在急性期,脑内出血在T1加权成像上表现为高信号。因此,很难将出血性胶质母细胞瘤与脑内出血区分开来。即使在常见部位观察到脑内出血,考虑恶性脑肿瘤的可能性并迅速完成检查也很重要。此外,ASL成像可能有助于检测出血性恶性脑肿瘤。