Bamarinejad Atefeh, Nasiri Shidrokh, Bamarinejad Fatemeh, Salehidoost Rezvan, Zare-Farashbandi Elahe
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2020 Aug 28;9:38. doi: 10.4103/abr.abr_96_20. eCollection 2020.
Prolactinomas are the most common type of functional pituitary tumors. Dopamine agonists is the most important drugs used in prolactinoma,have antagonistic effect with antipsychotic drugs used in schizophrenia. Conversely, dopamine antagonist drugs increase prolactin in patients with simultaneous schizophrenia. In the present case, we report a 29-year-old single male with schizophrenia who treated for 8 years with risperidone and presented with macroprolactinoma. Iatrogenic hyperprolactinemia is a well-known side effect of dopamine antagonist drugs for treatment in a patient with schizophrenia. On the other hand, it appears these drugs have the other side effects, such as drug- induced prolactinoma or boost growth.
泌乳素瘤是最常见的功能性垂体肿瘤类型。多巴胺激动剂是用于治疗泌乳素瘤的最重要药物，与用于治疗精神分裂症的抗精神病药物具有拮抗作用。相反，多巴胺拮抗剂药物会使同时患有精神分裂症的患者体内泌乳素水平升高。在本病例中，我们报告了一名29岁的单身男性精神分裂症患者，他使用利培酮治疗了8年，现患有大泌乳素瘤。医源性高泌乳素血症是多巴胺拮抗剂药物治疗精神分裂症患者时众所周知的副作用。另一方面，这些药物似乎还有其他副作用，如药物性泌乳素瘤或促进肿瘤生长。
