Gouriet Frédérique, Tissot-Dupont Hervé, Casalta Jean-Paul, Hubert Sandrine, Cammilleri Serge, Riberi Alberto, Lepidi Hubert, Habib Gilbert, Raoult Didier
Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France.
IHU Méditerranée Infection, Marseille, France.
Front Med (Lausanne). 2020 Sep 10;7:535. doi: 10.3389/fmed.2020.00535. eCollection 2020.
Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is an imaging technique largely used in the management of infective endocarditis and in the detection and staging of cancer. We evaluate our experience of incidental cancer detection by PET/CT during IE investigations and follow-up. Between 2009 and 2018, our center, which includes an "endocarditis team," managed 750 patients with IE in a prospective cohort. PET/CT became available in 2011 and was performed in 451 patients. Incidental diagnosis of cancer by PET/CT was observed in 36 patients and confirmed in 34 of them (7.5%) (colorectal = 17; lung = 7; lymphoma = 2; melanoma = 2; ovarian = 2; prostate = 1; bladder = 1; ear, nose, and throat = 1; brain = 1). A significant association has been found between colorectal cancer and and/or [12/26 vs. 6/33 for other cancers, = 0.025, odds ratio = 3.86 (1.19-12.47)]. Two patients had a negative PET/CT (a colon cancer and a bladder cancer), and two patients, with positive PET/CT, had a benign colorectal tumor. PET/CT had a sensitivity of 94-100% for the diagnosis of cancer in this patient. Whole-body PET/CT confirmed the high incidence of cancer in patients with IE and could now be proposed in these cases.
氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）是一种在感染性心内膜炎的管理以及癌症的检测和分期中广泛应用的成像技术。我们评估了在感染性心内膜炎（IE）检查和随访期间通过PET/CT偶然发现癌症的经验。2009年至2018年期间，我们中心（包括一个“心内膜炎团队”）对750例IE患者进行了前瞻性队列研究。PET/CT于2011年开始应用，451例患者接受了该检查。PET/CT偶然诊断出癌症的患者有36例，其中34例得到确诊（7.5%）（结直肠癌 = 17例；肺癌 = 7例；淋巴瘤 = 2例；黑色素瘤 = 2例；卵巢癌 = 2例；前列腺癌 = 1例；膀胱癌 = 1例；耳鼻喉癌 = 1例；脑癌 = 1例）。已发现结直肠癌与[其他癌症为12/26 vs. 6/33，P = 0.025，比值比 = 3.86（1.19 - 12.47）]之间存在显著关联。两名患者PET/CT结果为阴性（一名结肠癌和一名膀胱癌），两名PET/CT结果为阳性的患者患有良性结直肠肿瘤。在该患者群体中，PET/CT对癌症诊断的敏感性为94% - 100%。全身PET/CT证实了IE患者中癌症的高发病率，现在可以在这些病例中推荐使用。
