Elahi Sina, Miere Alexandra, El Ameen Ala, Souied Eric H
Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, 40 avenue de Verdun, 94000, Créteil, France.
Am J Ophthalmol Case Rep. 2020 Sep 29;20:100952. doi: 10.1016/j.ajoc.2020.100952. eCollection 2020 Dec.
To analyze using the high magnification module (HMM) a case of peripapillary congenital hypertrophy of retinal pigment epithelium (CHRPE) and to correlate the findings to multimodal imaging and swept-source optical coherence tomography angiography (SS-OCTA, PLEX® Elite 9000, Carl Zeiss Meditec, Dublin, California, USA) imaging.
A 57-year-old Caucasian woman presenting a peripapillary CHRPE of the left eye (LE) was examined using HMM and SS-OCTA, in addition to multimodal imaging. SS-OCTA disclosed the gradual changes, with four distinguishable zones: Zone 1 with complete outer retinal and retinal pigment epithelium (RPE) atrophy, Zones 2 and 3, corresponding to incomplete outer retinal (and RPE) atrophy presenting increased flow deficits, and normal choriocapillaris outside the lesion (Zone 4). High Magnification Module (HMM, Spectralis ®, Heidelberg Engineering) showed small polygonal hyperreflective outlines over the pigmented parts of the lesion (Zone 2), and partly over the narrow halo surrounding the lesion (Zone 3), with an absence of these outlines over the lacunae (Zone 1).
HMM is a non-invasive imaging modality, allowing the in vivo visualization of a mosaic pattern, corresponding to the hyperreflective polygonal outlines, or absence thereof, in different zones of CHRPE.
使用高倍放大模块（HMM）分析一例视乳头周围先天性视网膜色素上皮肥大（CHRPE）病例，并将结果与多模态成像和扫频光学相干断层扫描血管造影（SS-OCTA，PLEX® Elite 9000，卡尔蔡司医疗技术公司，美国加利福尼亚州都柏林）成像相关联。
一名57岁的白种女性，左眼患有视乳头周围CHRPE，除了进行多模态成像外，还使用HMM和SS-OCTA进行了检查。SS-OCTA显示出逐渐变化的情况，有四个可区分的区域：区域1为完全性外层视网膜和视网膜色素上皮（RPE）萎缩；区域2和区域3，对应不完全性外层视网膜（和RPE）萎缩，表现为血流缺失增加；病变外的脉络膜毛细血管正常（区域4）。高倍放大模块（HMM，Spectralis®，海德堡工程公司）显示，在病变的色素沉着部分（区域2）以及部分围绕病变的狭窄晕环（区域3）上有小的多边形高反射轮廓，而在缺损处（区域1）则没有这些轮廓。
HMM是一种非侵入性成像方式，能够在体内可视化对应于CHRPE不同区域高反射多边形轮廓或其缺失情况的镶嵌图案。
