血管紧张素II血管效应的内皮调节作用。

Modulation by endothelium of the vascular effects of angiotensin II.

作者信息

Yilmaz G, Aksulu H E, Demirel E, Ercan Z S, Zengil H, Türker R K

出版信息

Agents Actions. 1987 Jun;21(1-2):184-90. doi: 10.1007/BF01974940.

DOI:10.1007/BF01974940

Abstract

Modulation by vascular endothelium of the effects of AII was studied in the isolated rabbit aortic and superior mesenteric artery strips. The contractile effect of AII was enhanced in rubbed aortic strips. Similar enhancement was obtained in hydroquinone pretreated unrubbed strips. The relaxing effect of acetylcholine in AII--induced precontracted aortic strips was abolished after rubbing and hydroquinone pretreatment. However, no significant changes were observed in the contractile response to AII on aspirin and nicotine pretreated strips. In the isolated mesenteric artery strips AII produced a biphasic responses. The contractile effect of AII was enhanced in rubbed strips. Similar potentiation was also obtained in hydroquinone, aspirin and nicotine pretreated unrubbed strips. The relaxation phase of AII response was completely abolished in rubbed strips but partially inhibited in hydroquinone, aspirin and nicotine pretreated unrubbed strips. From these results it was concluded that EDRF is the main endothelial humoral factor which modulates the effect of AII in the rabbit aorta while both EDRF and PGI2 are involved for the modulation of the effects of octapeptide in the mesenteric artery.

摘要

在离体兔主动脉条和肠系膜上动脉条中研究了血管内皮对血管紧张素II（AII）作用的调节。在摩擦过的主动脉条中，AII的收缩作用增强。在对苯二酚预处理的未摩擦条中也获得了类似的增强效果。在摩擦和对苯二酚预处理后，乙酰胆碱在AII诱导的预收缩主动脉条中的舒张作用消失。然而，在阿司匹林和尼古丁预处理的条上，对AII的收缩反应未观察到显著变化。在离体肠系膜动脉条中，AII产生双相反应。在摩擦条中，AII的收缩作用增强。在对苯二酚、阿司匹林和尼古丁预处理的未摩擦条中也获得了类似的增强作用。在摩擦条中，AII反应的舒张期完全消失，但在对苯二酚、阿司匹林和尼古丁预处理的未摩擦条中部分受到抑制。从这些结果得出结论，内皮舒张因子（EDRF）是调节兔主动脉中AII作用的主要内皮体液因子，而EDRF和前列环素（PGI2）都参与了对肠系膜动脉中八肽作用的调节。