Department of Cardiovascular Surgery, 38548Tokyo Medical University, Tokyo, Japan.
Department of Surgery, Eniwa Midorino Clinic, Eniwa, Japan.
Vasc Endovascular Surg. 2021 Feb;55(2):112-116. doi: 10.1177/1538574420967130. Epub 2020 Oct 19.
The eicosapentaenoic acid to arachidonic acid ratio (EPA/AA) is attracting attention as a risk factor for peripheral artery disease (PAD). However, there have been few studies investigating the relationship between the EPA/AA ratio and atherosclerotic risk factors in patients with PAD. The purpose of the present study was to analyze atherosclerotic risk factors in patients with PAD to identify those factors associated with a low EPA/AA ratio.
METHODS.: The data of patients treated for symptomatic PAD at Tokyo Medical University Hospital and Eniwa Midorino Clinic between April 2014 and March 2018 were retrospectively analyzed.
RESULTS.: A total of 149 patients were tested for blood levels of n-3 and n-6 polyunsaturated fatty acids, including EPA and AA. 73 patients had a low EPA/AA ratio (<0.4) and 76 patients had a high EPA/AA ratio (≥ 0.4). Univariate analysis showed that older age (≥ 75 years), female sex, smoking history, body mass index (BMI), and hemoglobin A (HbA) were associated with the low EPA/AA ratio. Multivariable analysis showed that older age (odds ratio [OR], 0.34; 95% confidential interval [CI], 0.15-0.76; = 0.008), BMI (OR, 0.87; 95% CI, 0.77-0.98; = 0.027), smoking history (OR, 2.67; 95% CI, 1.09-6.55; = 0.007), and HbA (OR, 0.46; 95% CI, 0.29-0.72; = 0.020) were independently associated with the low EPA/AA ratio.
CONCLUSIONS.: The EPA/AA ratio was related to existing arteriosclerotic risk factors in patients with PAD; it was positively correlated with older age, increasing BMI, and higher HbA, whereas it was negatively correlated with smoking history. These results suggest that the EPA/AA ratio may be closely intertwined with other atherosclerotic risk factors and have an influence on cardiovascular health.
二十碳五烯酸与花生四烯酸的比值（EPA/AA）作为外周动脉疾病（PAD）的风险因素正受到关注。然而，关于 EPA/AA 比值与 PAD 患者动脉粥样硬化危险因素之间的关系的研究较少。本研究旨在分析 PAD 患者的动脉粥样硬化危险因素，确定与低 EPA/AA 比值相关的因素。
回顾性分析 2014 年 4 月至 2018 年 3 月在东京医科大学医院和恩尼瓦米多利诺诊所接受治疗的有症状 PAD 患者的数据。
共检测了 149 例患者的 n-3 和 n-6 多不饱和脂肪酸，包括 EPA 和 AA。73 例患者的 EPA/AA 比值较低（<0.4），76 例患者的 EPA/AA 比值较高（≥0.4）。单因素分析显示，年龄较大（≥75 岁）、女性、吸烟史、体重指数（BMI）和血红蛋白 A（HbA）与低 EPA/AA 比值有关。多因素分析显示，年龄较大（比值比 [OR]，0.34；95%置信区间 [CI]，0.15-0.76； = 0.008）、BMI（OR，0.87；95%CI，0.77-0.98； = 0.027）、吸烟史（OR，2.67；95%CI，1.09-6.55； = 0.007）和 HbA（OR，0.46；95%CI，0.29-0.72； = 0.020）与低 EPA/AA 比值独立相关。
EPA/AA 比值与 PAD 患者现有的动脉粥样硬化危险因素有关；与年龄较大、BMI 增加和 HbA 升高呈正相关，与吸烟史呈负相关。这些结果表明，EPA/AA 比值可能与其他动脉粥样硬化危险因素密切相关，对心血管健康有影响。
